{"id":"W2536396512","doi":"10.1016/s1470-2045(16)30508-3","title":"Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study","year":2016,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":643,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital","funders":"National Cancer Institute; AstraZeneca","keywords":"Osimertinib; Lung cancer; Medicine; Open label; Cancer; Oncology; Internal medicine; Adenocarcinoma; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001634801,0.002609258,0.002632469,0.0003979639,0.0004427932,0.001466171,0.000785864,0.00152619,0.003819875],"category_scores_gemma":[0.0007192465,0.0007965519,0.002139258,0.0004988929,0.001114857,0.001598369,0.0003868459,0.003209376,0.001123538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092339,"about_ca_system_score_gemma":0.001181345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282975,"about_ca_topic_score_gemma":0.004790141,"domain_scores_codex":[0.9995853,0.0001534898,0.00001699324,0.00008059953,0.00004155089,0.0001219128],"domain_scores_gemma":[0.999603,0.00005671899,0.0000751707,0.00004182718,0.00002759143,0.0001956562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8969789,0.02054895,0.003584526,0.0008601741,0.002161158,0.0001708666,0.0001908736,0.001831334,0.01752984,0.0002469678,0.003393343,0.05250306],"study_design_scores_gemma":[0.8189529,0.1677262,0.008059401,0.00002950567,0.0007482519,0.0001803492,0.00007494826,0.0009234325,0.001126028,0.0002561426,0.001880932,0.00004199925],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926468,0.002059298,0.0004438233,0.0003657614,0.0001955537,0.001365529,0.001201809,0.00009996919,0.001621411],"genre_scores_gemma":[0.9861974,0.002607797,0.001160447,0.0009731709,0.0002235665,0.001706324,0.002605241,0.0000539532,0.00447196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003819875,"threshold_uncertainty_score":0.01277876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06472232217388303,"score_gpt":0.4461270129553907,"score_spread":0.3814046907815077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}