{"id":"W2536598862","doi":"10.1016/j.mito.2016.10.005","title":"Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences","year":2016,"lang":"en","type":"review","venue":"Mitochondrion","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Mitochondrion; Drug; Adverse effect; Mitochondrial toxicity; Pharmacology; Mitochondrial permeability transition pore; Drug metabolism; Mitochondrial DNA; Mitochondrial disease; Reactive oxygen species; Medicine; Mechanism (biology); Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003020218,0.0005731962,0.0011626,0.000117892,0.0001340202,0.00004335115,0.0003719667,0.0008557806,0.000138988],"category_scores_gemma":[0.0002381472,0.0004150599,0.0005818005,0.0001236007,0.0002790329,0.000007457595,0.0002397623,0.0002925683,0.000188829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008071956,"about_ca_system_score_gemma":0.0004292988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001327821,"about_ca_topic_score_gemma":0.0000424769,"domain_scores_codex":[0.9968194,0.0005001662,0.0008989265,0.001132609,0.0002557584,0.0003931163],"domain_scores_gemma":[0.9984018,0.00007245772,0.0004489965,0.000747229,0.00008387467,0.0002456334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005910276,0.0000579437,0.000005176088,0.0006973345,0.0002212936,0.000008911922,0.00001369043,9.024264e-8,0.002416016,0.0003358274,0.01466903,0.9815156],"study_design_scores_gemma":[0.0008586663,0.0001824023,0.000005853751,0.001252236,0.0003627619,0.00005398239,0.00002518361,2.490455e-7,0.0002595928,0.0003406458,0.99612,0.0005384774],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002608183,0.9903513,0.00132867,0.0000689767,0.006075976,0.0009900229,0.00008235079,0.00002951955,0.0008123241],"genre_scores_gemma":[0.00002176096,0.991416,0.001570658,0.000139544,0.002038405,0.0001655687,0.0002649744,0.00006969954,0.004313332],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9814509,"threshold_uncertainty_score":0.9998301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307754671507433,"score_gpt":0.3285931784603937,"score_spread":0.2955156317453193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}