{"id":"W2537167978","doi":"10.1016/j.jalz.2016.06.2175","title":"P4‐086: TAU Modulates BDNF Expression and Mediates Aβ‐Induced Bdnf Down‐Regulation in Animal and Cellular Models of Alzheimer's Disease","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Neuroscience; Disease; Psychology; Tau pathology; Animal model; Brain-derived neurotrophic factor; Alzheimer's disease; Medicine; Internal medicine; Neurotrophic factors; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275119,0.0003813084,0.0004926069,0.000195887,0.0003136111,0.0002845293,0.0003799285,0.0005288097,0.00369379],"category_scores_gemma":[0.0001229214,0.0001376336,0.0003883058,0.0002087788,0.0003003857,0.0002067394,0.0001924087,0.001142359,0.001637852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263947,"about_ca_system_score_gemma":0.0003010144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238773,"about_ca_topic_score_gemma":0.001627995,"domain_scores_codex":[0.9998272,0.00001976534,0.00001597709,0.00003911684,0.00004589387,0.00005205667],"domain_scores_gemma":[0.9998984,0.000007939422,0.00002334648,0.000009350778,0.00001444267,0.00004644339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001141925,0.0002592017,0.0001428407,0.00009484764,0.0000118301,0.0000902203,0.00002568271,0.00004573237,0.9954293,0.00006839188,0.0003137388,0.002376294],"study_design_scores_gemma":[0.0003075206,0.004695171,0.01393868,0.00003767436,0.00007468335,0.0005945385,0.00009090744,0.000993854,0.9711487,0.0001787522,0.007921886,0.00001766122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992293,0.002089733,0.001149136,0.0003263006,0.0001210174,0.00006848195,0.001509531,0.0001447064,0.002298077],"genre_scores_gemma":[0.984211,0.0020116,0.001828692,0.000268966,0.00006067724,0.000242575,0.002205321,0.00007188002,0.009099233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00369379,"threshold_uncertainty_score":0.01235694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03460678202260288,"score_gpt":0.2471097334389317,"score_spread":0.2125029514163288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}