{"id":"W2537189179","doi":"10.1182/blood.v126.23.3935.3935","title":"Results of the Mantle Cell Lymphoma Subset from a Phase 2a Study of Copanlisib, a Novel PI3K Inhibitor, in Patients with Indolent and Aggressive Lymphoma","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Jewish General Hospital","funders":"","keywords":"Mantle cell lymphoma; Medicine; Internal medicine; Idelalisib; Lymphoma; Phases of clinical research; Chronic lymphocytic leukemia; Oncology; Progressive disease; Aggressive lymphoma; Clinical endpoint; Gastroenterology; Clinical trial; Ibrutinib; Rituximab; Leukemia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002852447,0.0002066393,0.0005020183,0.0001447593,0.0000280944,0.00001159977,0.0002255938,0.00009918358,0.000004319225],"category_scores_gemma":[0.0003521809,0.0001311013,0.00004124695,0.0004234663,0.0001968722,0.00006761317,0.0002802421,0.00009262636,0.000002949567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106766,"about_ca_system_score_gemma":0.003367302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005496838,"about_ca_topic_score_gemma":0.0005372885,"domain_scores_codex":[0.9975698,0.0001106514,0.0005564712,0.0004043483,0.001060407,0.000298316],"domain_scores_gemma":[0.9981568,0.0001598441,0.0004473544,0.0007195494,0.0003228898,0.0001935161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05933307,0.296381,0.5670418,0.0006626963,0.001024636,0.00117709,0.05452148,0.00003172042,0.005940093,0.000006473383,0.00182813,0.01205178],"study_design_scores_gemma":[0.7432682,0.006327652,0.203256,0.0007265077,0.0002674508,0.00003436166,0.002707565,0.0002338109,0.04295518,0.000007032948,0.00005212141,0.0001640962],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975242,0.0003787371,0.000001007347,0.00002141156,0.00006165715,0.001402571,0.0003551519,0.00001034339,0.0002449251],"genre_scores_gemma":[0.9996542,0.00001007014,0.0001007815,0.00003003179,0.00004655267,0.00003220755,0.00005191129,0.00002973105,0.00004456389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6839351,"threshold_uncertainty_score":0.830961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944986081040304,"score_gpt":0.2655987216363375,"score_spread":0.2461488608259345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}