{"id":"W2537189179","doi":"10.1182/blood.v126.23.3935.3935","title":"Results of the Mantle Cell Lymphoma Subset from a Phase 2a Study of Copanlisib, a Novel PI3K Inhibitor, in Patients with Indolent and Aggressive Lymphoma","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Jewish General Hospital","funders":"","keywords":"Mantle cell lymphoma; Medicine; Internal medicine; Idelalisib; Lymphoma; Phases of clinical research; Chronic lymphocytic leukemia; Oncology; Progressive disease; Aggressive lymphoma; Clinical endpoint; Gastroenterology; Clinical trial; Ibrutinib; Rituximab; Leukemia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597956,0.0007846745,0.00107536,0.0003120867,0.0004388847,0.0009278198,0.0005597683,0.0006438466,0.001600377],"category_scores_gemma":[0.000864799,0.0003878499,0.001045287,0.0003130474,0.0003375225,0.0005411016,0.0003804998,0.001806354,0.000477531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006567796,"about_ca_system_score_gemma":0.0007689353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009383529,"about_ca_topic_score_gemma":0.002049441,"domain_scores_codex":[0.9996038,0.0001491585,0.00003140249,0.00008061663,0.00006994228,0.00006502274],"domain_scores_gemma":[0.9993693,0.00008826789,0.00006487873,0.0000843052,0.00008701611,0.0003062701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2815712,0.03495377,0.1715214,0.0008427055,0.00398639,0.00227209,0.001264771,0.004273529,0.204438,0.0005870168,0.02059393,0.2736952],"study_design_scores_gemma":[0.1464126,0.3216293,0.4590182,0.0001405748,0.0044112,0.007255021,0.0005671905,0.005043985,0.02796306,0.00108432,0.02631528,0.0001592369],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914305,0.00206935,0.0006730721,0.0005555279,0.00003899737,0.0008644197,0.001946166,0.00007004695,0.002351881],"genre_scores_gemma":[0.9863253,0.0008752514,0.001875115,0.001269887,0.0001237633,0.000942242,0.007100387,0.00003021595,0.001457723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600377,"threshold_uncertainty_score":0.008450925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944986081040304,"score_gpt":0.2655987216363375,"score_spread":0.2461488608259345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}