{"id":"W2537241602","doi":"10.1182/blood.v110.11.2514.2514","title":"Pre-Clinical Validation of Polo-Like Kinase 1 as a Therapeutic Target in Multiple Myeloma with the Selective Inhibitor BI2536.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"PLK1; Cancer research; Bortezomib; Centrosome; Biology; Polo-like kinase; Mitosis; Multiple myeloma; Kinase; Cell cycle; Apoptosis; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009187874,0.0006887512,0.001044048,0.000395533,0.0003321204,0.0008725671,0.0007752366,0.0006221401,0.002373185],"category_scores_gemma":[0.0004203037,0.0002446425,0.0004573137,0.0005258108,0.0003591343,0.0003805284,0.0003630916,0.001778189,0.000897507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001171816,"about_ca_system_score_gemma":0.001080396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328549,"about_ca_topic_score_gemma":0.003903991,"domain_scores_codex":[0.9996705,0.00007200808,0.00002373442,0.00004762758,0.000105764,0.00008038063],"domain_scores_gemma":[0.9997448,0.000026496,0.00004898298,0.00002712051,0.00005725205,0.00009533954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01192773,0.00387212,0.004199771,0.0006971767,0.0002479491,0.0004652701,0.0001794286,0.001393313,0.9172676,0.0003126802,0.003153224,0.05628354],"study_design_scores_gemma":[0.003669029,0.07190605,0.03565171,0.000126569,0.0006713787,0.00224112,0.0001737535,0.002355302,0.8447968,0.0001916097,0.0381675,0.00004918406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735278,0.01550046,0.002312263,0.0009715174,0.0001399064,0.001011003,0.001816233,0.0003095677,0.004411223],"genre_scores_gemma":[0.9878216,0.003538346,0.002538143,0.000325765,0.00004063921,0.0003569948,0.002538119,0.00003614639,0.002804134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002373185,"threshold_uncertainty_score":0.008502126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009748020548177914,"score_gpt":0.2652101127762276,"score_spread":0.2554620922280497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}