{"id":"W2537342864","doi":"10.1210/en.2016-1508","title":"5α-Androstane-3α,17β-Diol Inhibits Neurotoxicity in SH-SY5Y Human Neuroblastoma Cells and Mouse Primary Cortical Neurons","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Forskningsrådet om Hälsa, Arbetsliv och Välfärd","keywords":"MAPK/ERK pathway; SH-SY5Y; Neurotoxicity; Endocrinology; Internal medicine; Neuroprotection; Biology; Phosphorylation; Chemistry; Epidermal growth factor; Cancer research; Cell biology; Medicine; Neuroblastoma; Cell culture; Toxicity; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668999,0.0007331955,0.0005505463,0.0005007149,0.0002248447,0.0002251425,0.0002451062,0.0002431262,0.001336878],"category_scores_gemma":[0.00006830689,0.0002164522,0.0005478421,0.0004262272,0.0001910824,0.000143451,0.0001649034,0.0005319354,0.0003918389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229441,"about_ca_system_score_gemma":0.0005878657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003313001,"about_ca_topic_score_gemma":0.008675329,"domain_scores_codex":[0.9998702,0.00001550424,0.00002514223,0.00002060988,0.00002910792,0.00003948233],"domain_scores_gemma":[0.9999318,0.000009081306,0.00001693978,0.000007561089,0.00001088492,0.00002378273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003898619,0.0001308339,0.0002383027,0.0001035719,0.00002067447,0.00008656693,0.00003441002,0.00006956552,0.9975356,0.00003289482,0.00007400409,0.001283716],"study_design_scores_gemma":[0.00009602896,0.002360079,0.01496934,0.00002611163,0.0000569902,0.0001768257,0.00008297223,0.0006104077,0.9795044,0.00005266024,0.002055638,0.000008529511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933257,0.003408211,0.0004379258,0.00008294418,0.00005999481,0.00003831298,0.0008638861,0.00006158753,0.001721347],"genre_scores_gemma":[0.9802018,0.008745649,0.001568329,0.0001017246,0.00002836138,0.0001490097,0.002398354,0.00002597662,0.006780773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003313001,"threshold_uncertainty_score":0.006587446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006418159974622362,"score_gpt":0.2244243847210267,"score_spread":0.2180062247464043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}