{"id":"W2537525060","doi":"10.1016/j.immuni.2016.09.015","title":"Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion","year":2016,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; Searle Scholars Program; Ragon Institute of MGH, MIT and Harvard; U.S. Department of Defense; Oregon Health and Science University; Fonds de recherche du Québec; Bill and Melinda Gates Foundation; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; Fonds de Recherche du Québec-Société et Culture; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Biology; CD8; Human leukocyte antigen; Cytotoxic T cell; T-cell receptor; Virology; Immunology; Major histocompatibility complex; MHC class I; Antigen; T cell; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299086,0.0001064345,0.00007179266,0.0001960256,0.0001353307,0.0002886359,0.0001081669,0.0001636158,0.001956142],"category_scores_gemma":[0.0003385008,0.00007112628,0.00005082542,0.00009311911,0.0001672882,0.0002171743,0.0001646955,0.0002820776,0.0003685499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008954014,"about_ca_system_score_gemma":0.000090576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001151529,"about_ca_topic_score_gemma":0.0002504651,"domain_scores_codex":[0.999926,0.00001482928,0.000004900772,0.0000123283,0.00001517769,0.00002685039],"domain_scores_gemma":[0.9998249,0.00005051195,0.00002777025,0.00003151256,0.00002816136,0.00003721358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002163002,0.00006154715,0.0154218,0.00003275135,0.000006594943,0.0002906197,0.000127464,0.00008896375,0.9672263,0.0006117965,0.0001782149,0.0157376],"study_design_scores_gemma":[0.0001704837,0.001726885,0.3076715,0.00008261756,0.00008901265,0.007635387,0.0008129315,0.003478278,0.6545999,0.003507567,0.0202026,0.00002287037],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997558,0.0004402777,0.0004336956,0.00002651802,0.000008714617,0.000008101116,0.00004110768,0.00001910713,0.001464474],"genre_scores_gemma":[0.9981086,0.0001917775,0.0003171368,0.00002280988,0.0000192528,0.00001285528,0.00009509985,0.000004247618,0.001228115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001956142,"threshold_uncertainty_score":0.006543934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009332718095657107,"score_gpt":0.230197468314691,"score_spread":0.2208647502190339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}