{"id":"W2537525060","doi":"10.1016/j.immuni.2016.09.015","title":"Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion","year":2016,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; Searle Scholars Program; Ragon Institute of MGH, MIT and Harvard; U.S. Department of Defense; Oregon Health and Science University; Fonds de recherche du Québec; Bill and Melinda Gates Foundation; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; Fonds de Recherche du Québec-Société et Culture; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Biology; CD8; Human leukocyte antigen; Cytotoxic T cell; T-cell receptor; Virology; Immunology; Major histocompatibility complex; MHC class I; Antigen; T cell; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159353,0.0002443389,0.0002457712,0.0001708152,0.001238716,0.00003339902,0.0001256185,0.0002853991,0.000454874],"category_scores_gemma":[0.00005365356,0.0001912366,0.00009695017,0.0001383524,0.0002430134,0.0004843618,0.0002064607,0.0005851744,0.000322752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344071,"about_ca_system_score_gemma":0.00002645549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006818633,"about_ca_topic_score_gemma":0.00003947008,"domain_scores_codex":[0.9985361,0.0003823688,0.0003564448,0.0003120185,0.00005296618,0.0003601751],"domain_scores_gemma":[0.9992763,0.00008209684,0.0001871598,0.0003292708,0.0001014147,0.00002378851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688331,0.0001384502,0.004330456,0.00001109966,0.00006522706,0.000001903992,0.0001583722,1.727527e-7,0.9817103,0.00004529284,0.01165825,0.001511634],"study_design_scores_gemma":[0.001953476,0.0002107264,0.1310758,0.00007130367,0.00001760816,0.00004983035,0.00006718063,0.000001776266,0.8222007,0.00001702843,0.04409898,0.0002355837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946438,0.0007935644,0.00003852234,0.0001371672,0.002536488,0.0001735128,0.00001268119,0.0001752065,0.001489036],"genre_scores_gemma":[0.9682736,0.0004522517,0.000005979105,0.00005726888,0.00004872633,0.000008979402,0.0002378874,0.00002199821,0.03089326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1595096,"threshold_uncertainty_score":0.952733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009332718095657107,"score_gpt":0.230197468314691,"score_spread":0.2208647502190339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}