{"id":"W2537902732","doi":"10.1021/acs.langmuir.6b03253","title":"Parallel Polyadenine Duplex Formation at Low pH Facilitates DNA Conjugation onto Gold Nanoparticles","year":2016,"lang":"en","type":"article","venue":"Langmuir","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Chemistry; Conjugate; Colloidal gold; Circular dichroism; Base pair; Combinatorial chemistry; Biophysics; Stereochemistry; Crystallography; Nanoparticle; Nanotechnology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008719798,0.0001225294,0.0001122792,0.00003001022,0.00006900982,0.00001316285,0.00008254217,0.00009925861,0.000008676189],"category_scores_gemma":[0.00004267181,0.00007991932,0.00007310924,0.00005728631,0.00007195763,0.00001281826,0.00005895746,0.00002214562,0.00003814181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003307093,"about_ca_system_score_gemma":0.000006714327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001111112,"about_ca_topic_score_gemma":0.00008574842,"domain_scores_codex":[0.9992701,0.00003857971,0.0001784714,0.0002178779,0.0001027057,0.0001922627],"domain_scores_gemma":[0.9995954,0.00001139647,0.00008331258,0.000201176,0.00006306468,0.00004561959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000695362,0.00002039388,0.0006436968,0.000008723197,0.00001814588,0.00000111303,0.00003644775,0.0000013685,0.9910448,0.00004510877,0.004239015,0.003871706],"study_design_scores_gemma":[0.0003434098,0.00009572992,0.001572331,0.00001788042,0.00001338311,0.000009655567,0.0000358546,0.00003853618,0.9778141,0.00007627084,0.01983517,0.0001476856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962872,0.0001924359,0.002160565,0.00096522,0.0000227167,0.00009441686,0.00003743929,0.00007327367,0.0001667632],"genre_scores_gemma":[0.9948179,0.0001198935,0.001292224,0.0001825592,0.00009260081,0.00001173363,0.0001722902,0.00001079608,0.003300023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01559616,"threshold_uncertainty_score":0.3259015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009701051913622378,"score_gpt":0.2434249985142496,"score_spread":0.2337239466006272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}