{"id":"W2538078583","doi":"10.1097/fpc.0000000000000253","title":"Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder","year":2016,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Health and Medical Research Council; Pfizer Australia; Pfizer","keywords":"Concordance; Dosing; Pharmacogenetics; Major depressive disorder; Medicine; Internal medicine; Clinical trial; Psychiatry; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001478796,0.0003479483,0.0004384208,0.0001947924,0.0001035193,0.00002707223,0.0001303907,0.0001209026,0.00006788222],"category_scores_gemma":[0.0000618609,0.0002511623,0.00004909806,0.0001722286,0.0001118402,0.00006408799,0.0002642765,0.0001591972,0.00001071408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009651332,"about_ca_system_score_gemma":0.0000843158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003857227,"about_ca_topic_score_gemma":0.00001218093,"domain_scores_codex":[0.9981952,0.00007696463,0.000430112,0.0006148217,0.000235812,0.0004470926],"domain_scores_gemma":[0.9987245,0.000187361,0.0001174406,0.0002656885,0.00007099123,0.0006340449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001297593,0.0001329621,0.191686,0.00005394769,0.0001089043,0.00004660756,0.0003798449,0.00001878598,0.6188266,0.00000128892,0.0003436597,0.1871037],"study_design_scores_gemma":[0.03285104,0.001202911,0.4085389,0.0004841409,0.0008446179,0.0001162412,0.0001164319,0.0007554232,0.5274764,0.0002069596,0.02668669,0.0007203306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904464,0.003885615,0.0007973659,0.003326387,0.0001161729,0.001117866,0.0001868427,0.0000484288,0.00007487544],"genre_scores_gemma":[0.9909059,0.005417814,0.002320612,0.0006836075,0.0002369233,0.00006481166,0.00003428767,0.00006677933,0.0002692016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2168529,"threshold_uncertainty_score":0.999994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902269903173915,"score_gpt":0.3023839319443738,"score_spread":0.2833612329126347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}