{"id":"W2538078583","doi":"10.1097/fpc.0000000000000253","title":"Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder","year":2016,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Health and Medical Research Council; Pfizer Australia; Pfizer","keywords":"Concordance; Dosing; Pharmacogenetics; Major depressive disorder; Medicine; Internal medicine; Clinical trial; Psychiatry; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01038012,0.0002064888,0.0004005431,0.0006274816,0.0002204857,0.0006611197,0.0005278728,0.0004742309,0.0008780688],"category_scores_gemma":[0.03852099,0.0002396005,0.0004120841,0.0005210732,0.0003262481,0.0003204813,0.0004776364,0.0005061663,0.0002431577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965599,"about_ca_system_score_gemma":0.0002564542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363438,"about_ca_topic_score_gemma":0.001459543,"domain_scores_codex":[0.9931669,0.004127387,0.0008344031,0.0008302417,0.0009268227,0.0001143192],"domain_scores_gemma":[0.9605325,0.0257161,0.0091444,0.002784926,0.001479575,0.0003424526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001330199,0.00009464321,0.9873236,0.00004027257,0.0003193922,0.0000316034,0.0001938829,0.0009192695,0.0003063841,0.00009106359,0.0001222586,0.009227478],"study_design_scores_gemma":[0.00006667517,0.0004865404,0.9941975,0.00001765825,0.0000943984,0.0002185136,0.00004716399,0.004023609,0.0005296818,0.0001190853,0.0001899754,0.000009190512],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977739,0.0001945692,0.001012764,0.00002881695,0.00000920793,0.00002142401,0.0002572364,0.00001086455,0.0006911361],"genre_scores_gemma":[0.9992276,0.00002669626,0.0004685297,0.00000857088,0.000002869973,0.000008967875,0.000199581,0.000001970086,0.00005517363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01038012,"threshold_uncertainty_score":0.054896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902269903173915,"score_gpt":0.3023839319443738,"score_spread":0.2833612329126347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}