{"id":"W2538239144","doi":"10.1021/acs.chemrestox.6b00278","title":"<i>O</i><sup>6</sup>-2′-Deoxyguanosine-butylene-<i>O</i><sup>6</sup>-2′-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions","year":2016,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Army Research Office; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Central Michigan University","keywords":"DNA polymerase; Guanine; Deoxyguanosine; DNA; DNA replication; Polymerase; Molecular biology; DNA damage; DNA repair; Chemistry; Biology; Nucleotide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191127,0.0003928605,0.0001667413,0.0001217258,0.0001209706,0.0001633854,0.0001949573,0.0003066755,0.0009605236],"category_scores_gemma":[0.0001506916,0.0001115191,0.0002025378,0.0001383455,0.0002123724,0.0001853519,0.0001481717,0.0003357918,0.0003289939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011944,"about_ca_system_score_gemma":0.0001648072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002481227,"about_ca_topic_score_gemma":0.0003001281,"domain_scores_codex":[0.9998777,0.00001617472,0.000007593964,0.00003410195,0.00003791638,0.0000264755],"domain_scores_gemma":[0.9998446,0.00001529922,0.00008269909,0.00001368996,0.00001952215,0.00002421276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003257415,0.00001132461,0.0001573807,0.00004553611,0.00000237179,0.00002914808,0.000006808477,0.0001207908,0.9982988,0.0001121001,0.00001710825,0.001166077],"study_design_scores_gemma":[0.000002634228,0.0002773964,0.0005740832,0.000002031404,0.000004770466,0.00007603228,0.000006968173,0.0002349856,0.9972625,0.00001639043,0.001539456,0.000002829863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776367,0.002085961,0.01581224,0.0001003487,0.00005834116,0.00009095817,0.0002504796,0.0001388309,0.003826069],"genre_scores_gemma":[0.9867983,0.0009985849,0.008762723,0.00008074477,0.000007923487,0.00003697967,0.0003470445,0.00002307962,0.00294449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009605236,"threshold_uncertainty_score":0.003213286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04720652120796722,"score_gpt":0.3563774824045368,"score_spread":0.3091709611965696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}