{"id":"W2538736652","doi":"10.1016/j.jalz.2016.06.1494","title":"P2‐124: Brain Isoprenoids and Alzheimer's Disease","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Mevalonate pathway; Farnesyl pyrophosphate; Geranylgeranyl pyrophosphate; RHOA; Prenylation; CDC42; Terpenoid; Chemistry; Alzheimer's disease; GTPase; Biology; Biochemistry; Cell biology; Internal medicine; Signal transduction; Disease; Medicine; ATP synthase; Enzyme; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298713,0.0004979088,0.0002465942,0.0004069285,0.0002329041,0.0005164322,0.0002659302,0.0004288185,0.002900903],"category_scores_gemma":[0.0000731504,0.00008880121,0.0001897171,0.0003829671,0.0002284361,0.0002209278,0.000242289,0.0005615778,0.0009566926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514969,"about_ca_system_score_gemma":0.0003461599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001632041,"about_ca_topic_score_gemma":0.001863005,"domain_scores_codex":[0.9999326,0.00001211173,0.000005315291,0.00001711179,0.00001956637,0.00001326118],"domain_scores_gemma":[0.9999505,0.000003526363,0.0000112613,0.000002277286,0.00001681168,0.00001566311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004850996,0.000732105,0.01701983,0.001667121,0.0001297125,0.003096779,0.000188348,0.0001441821,0.8581362,0.0007841564,0.004521878,0.1087287],"study_design_scores_gemma":[0.0003187818,0.004528185,0.5603823,0.0004935998,0.0003369937,0.01255017,0.0006788936,0.0006726774,0.3217196,0.003401171,0.09483949,0.00007809506],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8114963,0.1593955,0.002634129,0.002033761,0.000467502,0.0001743756,0.00369385,0.0001409589,0.01996358],"genre_scores_gemma":[0.9176667,0.04679599,0.003270104,0.0006126964,0.0003825861,0.0002024654,0.003467367,0.00002108764,0.02758094],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002900903,"threshold_uncertainty_score":0.009704471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275307688609726,"score_gpt":0.2327530434413827,"score_spread":0.2199999665552855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}