{"id":"W2538756717","doi":"10.1038/onc.2016.235","title":"CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Alberta Innovates; Stem Cell Network; McMaster University","keywords":"Medulloblastoma; STAT3; Biology; Carcinogenesis; Cancer research; Radiation therapy; Metastasis; Chemotherapy; Brain tumor; Tumor initiation; Brain metastasis; In vivo; Signal transduction; Oncology; Internal medicine; Cancer; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676719,0.0002377768,0.0003923843,0.0001419004,0.00009101936,0.00002272778,0.0001373471,0.00005342923,0.0007147206],"category_scores_gemma":[0.0002706806,0.0001704035,0.0001256192,0.0002228929,0.00003598589,0.00005519108,0.0000763142,0.0001407943,0.0005741582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000297629,"about_ca_system_score_gemma":0.0001898613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000059232,"about_ca_topic_score_gemma":0.0001308869,"domain_scores_codex":[0.9980621,0.00007486077,0.0003477207,0.0005242807,0.0005206277,0.0004704242],"domain_scores_gemma":[0.9985612,0.000285826,0.0001842317,0.0003889741,0.00014806,0.0004317053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002904722,0.0001219585,0.0005499474,0.00005388277,0.00005514817,0.000304517,0.0003713352,0.00003752679,0.8568418,0.00002629584,0.004680387,0.1366667],"study_design_scores_gemma":[0.001585325,0.0008275982,0.0004129437,0.001126039,0.00007275942,0.0000442704,0.0003666598,0.000007729214,0.9605971,0.00003571635,0.03465488,0.0002689563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886427,0.0002701747,0.003038367,0.003571714,0.000632836,0.0005239486,0.0002061084,0.00008207757,0.00303209],"genre_scores_gemma":[0.9894876,0.00006896421,0.003650148,0.004641375,0.0005148978,0.00005097469,0.000007060587,0.00004877409,0.00153021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1363978,"threshold_uncertainty_score":0.782569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508374225086481,"score_gpt":0.2896440148393604,"score_spread":0.2645602725884956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}