{"id":"W2538778544","doi":"10.1038/nchem.2636","title":"Oxadiazole grafts in peptide macrocycles","year":2016,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Peptidomimetic; Peptide; Cyclic peptide; Intramolecular force; Oxadiazole; Aldehyde; Combinatorial chemistry; Amine gas treating; Hydrogen bond; Molecule; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007594125,0.000155068,0.0001064913,0.0001314505,0.0001323982,0.0002488951,0.0001676284,0.0001454945,0.001658737],"category_scores_gemma":[0.00009949189,0.0001009844,0.00005650154,0.0001231095,0.0001702088,0.0002448357,0.000252789,0.0002947834,0.0003361723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229252,"about_ca_system_score_gemma":0.00009748115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003341368,"about_ca_topic_score_gemma":0.0007183761,"domain_scores_codex":[0.9999539,0.000005593513,0.00000277308,0.000008760585,0.000009695381,0.00001943459],"domain_scores_gemma":[0.9999633,0.00000819773,0.000008954617,0.00000503999,0.000002999819,0.00001159905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723595,0.00003753605,0.0002241832,0.00005673318,0.000004438083,0.0002426293,0.0000799414,0.00107065,0.9851829,0.005888793,0.0002271852,0.006812542],"study_design_scores_gemma":[0.00002815707,0.0006000397,0.001320957,0.000008883264,0.000008278739,0.0002063872,0.00003632547,0.001897837,0.9873384,0.0006178719,0.00792617,0.00001075285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921201,0.000729643,0.002137977,0.00005149515,0.00003240803,0.00001188226,0.00005091191,0.00006436495,0.004801203],"genre_scores_gemma":[0.9959266,0.0004311868,0.0007927261,0.00002375677,0.000006114704,0.000008695274,0.0000314498,0.00001255973,0.002766833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658737,"threshold_uncertainty_score":0.005549014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002142834418314491,"score_gpt":0.2149833660773124,"score_spread":0.2128405316589979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}