{"id":"W2538838702","doi":"10.1016/j.yrtph.2016.10.014","title":"Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society","year":2016,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Health Canada; World Health Organization","keywords":"Hazard; Categorization; Context (archaeology); Risk analysis (engineering); Risk assessment; Identification (biology); Hazard analysis; Business; Environmental health; Computer science; Medicine; Engineering; Computer security; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04874902,0.002214276,0.001823728,0.01370589,0.003215566,0.008071958,0.005376216,0.004303685,0.007723765],"category_scores_gemma":[0.04639091,0.0006340379,0.002662101,0.009286355,0.01263399,0.0129162,0.005432634,0.01017991,0.005074119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007437417,"about_ca_system_score_gemma":0.008002449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006097143,"about_ca_topic_score_gemma":0.005236526,"domain_scores_codex":[0.971154,0.01106692,0.003635163,0.002339242,0.01093283,0.0008718548],"domain_scores_gemma":[0.9185979,0.03142217,0.007617251,0.01388886,0.02685023,0.001623562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00009066702,0.0001120409,0.002375155,0.001317366,0.00007418355,0.00008647862,0.001258845,0.001801532,0.001511427,0.8005949,0.04065862,0.1501188],"study_design_scores_gemma":[0.00003429962,0.0003143475,0.003863194,0.001669056,0.0000890272,0.0003815116,0.001218165,0.003389541,0.002271563,0.4451099,0.5414377,0.0002216561],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.01296728,0.04941927,0.6851445,0.03527138,0.01347193,0.002008013,0.004176781,0.001929081,0.1956117],"genre_scores_gemma":[0.1644899,0.0379594,0.7129326,0.01742917,0.00473434,0.002638057,0.007053574,0.000899151,0.05186384],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04874902,"threshold_uncertainty_score":0.2578125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382932277569559,"score_gpt":0.3145780301533169,"score_spread":0.2907487073776213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}