{"id":"W2539044895","doi":"10.2337/db16-0234","title":"National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities","year":2016,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; University of Alberta; Feinberg School of Medicine; Leonard M. Miller School of Medicine, University of Miami; Perelman School of Medicine, University of Pennsylvania; Novo Nordisk Fonden; University of California, San Francisco; University of Illinois at Urbana-Champaign; University of Minnesota; Northwestern University; Emory University; National Center for Research Resources; Leonard M. Miller School of Medicine; University of Pennsylvania; Faculty of Medicine and Dentistry, University of Alberta; University of Miami","keywords":"Transplantation; Medicine; Clinical trial; Product (mathematics); Good manufacturing practice; Manufacturing engineering; Operations management; Engineering; Surgery; Internal medicine; Regulatory affairs","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008908755,0.0001703931,0.0007311628,0.0001589631,0.00007758485,0.000006327771,0.00006820907,0.00008396072,0.0003892279],"category_scores_gemma":[0.0008746794,0.0001121032,0.0001604504,0.0001274473,0.0004322602,0.0001267632,0.00001258755,0.00007592511,0.0000134358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000566117,"about_ca_system_score_gemma":0.0004020921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000745267,"about_ca_topic_score_gemma":7.678679e-7,"domain_scores_codex":[0.9978095,0.0002032965,0.001024907,0.0002948766,0.000430285,0.00023715],"domain_scores_gemma":[0.9983963,0.0005526278,0.0004607889,0.0001844377,0.0003007675,0.0001050675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01934297,0.00228936,0.04718475,0.004722594,0.000434361,0.000004551285,0.00118721,0.00000473205,0.8702383,0.0003888849,0.009807234,0.04439506],"study_design_scores_gemma":[0.0605847,0.001609971,0.01382189,0.0007205635,0.0001719351,0.000002991359,0.0001062607,0.0001305635,0.9040068,0.0003155262,0.01831684,0.0002119685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949989,0.0009840206,0.0001817323,0.001631975,0.0002535202,0.0007154727,0.0005044771,0.0000487329,0.000681185],"genre_scores_gemma":[0.9974763,0.0001045174,0.0005758678,0.0003353906,0.0001729466,0.00003935102,0.0004030968,0.0000135222,0.0008789756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04418309,"threshold_uncertainty_score":0.4571434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08117609451133721,"score_gpt":0.3535758101315311,"score_spread":0.2723997156201938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}