{"id":"W2539108032","doi":"10.1186/s13059-016-1079-9","title":"Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Planning and Budgeting Committee of the Council for Higher Education of Israel; Israel Science Foundation; Azrieli Foundation; Israeli Centers for Research Excellence; European Research Council; Agence Nationale de la Recherche","keywords":"Biology; Immune system; Alternative splicing; RNA splicing; Cell biology; Autoimmunity; Mediator; RNA-binding protein; RNA; Gene; Immunology; Genetics; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577027,0.0001352216,0.0001881342,0.0002262425,0.0001363522,0.0004440689,0.0001582946,0.0002389339,0.001846593],"category_scores_gemma":[0.0002178248,0.000083495,0.000196331,0.0001435934,0.0001715982,0.0001638959,0.0002606336,0.0002530333,0.0004470569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110737,"about_ca_system_score_gemma":0.00009840849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000153188,"about_ca_topic_score_gemma":0.0002392384,"domain_scores_codex":[0.9998505,0.00002008446,0.00001113588,0.00004595446,0.00004074012,0.00003159106],"domain_scores_gemma":[0.9997179,0.00007045232,0.00006260783,0.00004219923,0.00004295507,0.0000639956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003874821,0.000004851752,0.0009493909,0.00001058826,0.000002663454,0.00005331355,0.00001598993,0.00001499316,0.9981318,0.00005687828,0.000008131892,0.0007126638],"study_design_scores_gemma":[0.00001413457,0.0003613919,0.07542144,0.0000107049,0.00003262446,0.001822398,0.0002028058,0.0009242566,0.9163381,0.0002708476,0.004592602,0.000008698815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958184,0.0008385558,0.001943333,0.0000311455,0.00001097675,0.000006060868,0.0001231534,0.00003961348,0.001188735],"genre_scores_gemma":[0.9980459,0.000165064,0.0007499319,0.00002123945,0.000008769766,0.000004961396,0.0001778732,0.00001152098,0.0008147342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846593,"threshold_uncertainty_score":0.006177425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008918914445389883,"score_gpt":0.2339004628432524,"score_spread":0.2249815483978625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}