{"id":"W2539214151","doi":"10.1017/cjn.2016.379","title":"PC3 - 151 Toca 5: A Phase 2/3 Randomized, Open-Label Study of Toca 511, a Retroviral Replicating Vector, Combined with Toca FC versus Standard of Care in Patients Undergoing Planned Resection for Recurrent Glioblastoma (GBM) or Anaplastic Astrocytoma (AA) (NCT02414165)","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Clinical endpoint; Phases of clinical research; Clinical trial; Immune system; Internal medicine; Oncology; Gastroenterology; Surgery; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002128423,0.002323095,0.002170234,0.000772589,0.0006113321,0.001224267,0.001333087,0.00261233,0.00872124],"category_scores_gemma":[0.001358419,0.0007823369,0.001780054,0.0006467258,0.001502941,0.001241834,0.000401191,0.004348224,0.001428611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001435567,"about_ca_system_score_gemma":0.002972253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002282286,"about_ca_topic_score_gemma":0.006329953,"domain_scores_codex":[0.9994084,0.0002679283,0.00002414392,0.0001038939,0.00005899281,0.0001366542],"domain_scores_gemma":[0.9989855,0.0002318169,0.0002048507,0.00005913285,0.00006733485,0.0004514008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9082087,0.04710147,0.0009089065,0.0006012675,0.0007712352,0.00008426514,0.0001193016,0.0008652948,0.01066045,0.0003353308,0.002968248,0.02737548],"study_design_scores_gemma":[0.7668158,0.2288712,0.001300234,0.000020009,0.0002397951,0.00004042808,0.00002898676,0.0006358881,0.000871136,0.0001781066,0.0009792702,0.00001911207],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762337,0.002370917,0.001082847,0.0008291296,0.0004714548,0.01212583,0.0031034,0.000322567,0.003460238],"genre_scores_gemma":[0.9653618,0.002270621,0.003772376,0.002740787,0.0004617987,0.01461031,0.004107282,0.00008888715,0.006586102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00872124,"threshold_uncertainty_score":0.0291754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04031400826708335,"score_gpt":0.3363246228366942,"score_spread":0.2960106145696108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}