{"id":"W2539305318","doi":"10.4049/jimmunol.1601382","title":"Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CD1D; T-cell receptor; Priming (agriculture); Cell biology; Avidity; Biology; Effector; T cell; Immunology; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003544698,0.0003226856,0.0002405192,0.000167689,0.0001483191,0.0007628985,0.0002396611,0.0002467002,0.001359845],"category_scores_gemma":[0.0006744904,0.0002052692,0.000156459,0.0001622847,0.0003395613,0.0004836204,0.0002899272,0.0007125037,0.000476601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004524795,"about_ca_system_score_gemma":0.0002041843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001094752,"about_ca_topic_score_gemma":0.0001906844,"domain_scores_codex":[0.9994986,0.0001124709,0.00004946093,0.0001302724,0.0001168682,0.00009233276],"domain_scores_gemma":[0.9993838,0.0002031104,0.0002089151,0.00007657251,0.00004466691,0.00008288184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008410847,0.00001422282,0.0002580431,0.00001136186,0.000001681719,0.00001275791,0.000009287589,0.0001209165,0.998533,0.0001289612,0.000007350522,0.0008182438],"study_design_scores_gemma":[0.000006108999,0.00004673671,0.001061939,0.000001769292,0.000005039725,0.00006149655,0.00001097555,0.001668409,0.9967487,0.00005897834,0.0003271418,0.000002772868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904076,0.0004895717,0.007944359,0.00004078027,0.00001777948,0.00001347339,0.00009361532,0.00007710748,0.000915685],"genre_scores_gemma":[0.9975346,0.0001971172,0.001788484,0.00001643044,0.000005440059,0.00001058034,0.00004205394,0.00004836078,0.0003568935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359845,"threshold_uncertainty_score":0.004549146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007606916130565829,"score_gpt":0.2054571097468045,"score_spread":0.1978501936162387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}