{"id":"W2539421776","doi":"10.1038/srep35383","title":"CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Triple-negative breast cancer; Breast cancer; Cancer research; Cancer; Medicine; Cancer stem cell; CA15-3; Cyclin-dependent kinase 4; Stem cell; Oncology; Internal medicine; Biology; Cell cycle; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006324399,0.000189544,0.0003758013,0.0001262486,0.0002183761,0.00008795562,0.00005693423,0.00006632568,0.001100748],"category_scores_gemma":[0.00004074595,0.0001127363,0.0001329815,0.0003143117,0.0003534108,0.0001525197,0.00003781579,0.0000532332,0.000002512887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001496911,"about_ca_system_score_gemma":0.0004974469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005431271,"about_ca_topic_score_gemma":0.0001987364,"domain_scores_codex":[0.9980181,0.00001378324,0.000393614,0.0008188909,0.0003800541,0.0003755001],"domain_scores_gemma":[0.9984999,0.00005786861,0.0002866958,0.0005219013,0.0004303196,0.0002032577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006447493,0.000255707,0.0298735,0.0004624355,0.0005085226,0.00005602343,0.001665172,0.000004213506,0.6624256,0.00009695688,0.06092183,0.2430852],"study_design_scores_gemma":[0.004606244,0.0001399148,0.03699711,0.001047223,0.0006019947,0.0007558573,0.0002939325,0.0001061451,0.5168594,0.005301616,0.4327429,0.0005476636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586238,0.007995724,0.002368417,0.01383934,0.01290023,0.002693729,0.001006695,0.0001034154,0.0004686912],"genre_scores_gemma":[0.9447836,0.0002432597,0.0008725263,0.000376798,0.000308884,0.0004410728,0.00001274261,0.00003976188,0.05292134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3718211,"threshold_uncertainty_score":0.9998124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992360517203414,"score_gpt":0.3068430765383842,"score_spread":0.27691947136635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}