{"id":"W2539421776","doi":"10.1038/srep35383","title":"CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Triple-negative breast cancer; Breast cancer; Cancer research; Cancer; Medicine; Cancer stem cell; CA15-3; Cyclin-dependent kinase 4; Stem cell; Oncology; Internal medicine; Biology; Cell cycle; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436675,0.0002120578,0.0003114598,0.0003037019,0.0001622654,0.0004572749,0.0001849711,0.0001715277,0.001162541],"category_scores_gemma":[0.000104544,0.00009302256,0.0001306231,0.0001848505,0.0002562382,0.0001870697,0.0001513774,0.000468381,0.0002712456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006014417,"about_ca_system_score_gemma":0.0004922804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006363668,"about_ca_topic_score_gemma":0.001465303,"domain_scores_codex":[0.9999518,0.000007810848,0.000003695954,0.000007404937,0.00001302228,0.00001629685],"domain_scores_gemma":[0.9999672,0.000005712817,0.000008033117,0.000003422724,0.000005131653,0.00001048864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001079152,0.0001606755,0.003268984,0.0003653018,0.00003453804,0.0004717084,0.00004947298,0.0009237354,0.9314251,0.002949435,0.001417033,0.05785482],"study_design_scores_gemma":[0.0002405433,0.000967177,0.01168662,0.0000424811,0.00009157855,0.002286283,0.00009933916,0.002795892,0.9240605,0.001186636,0.05652449,0.00001856747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9248815,0.05711724,0.004548931,0.001894948,0.0002348408,0.0001231313,0.0006000416,0.0002083743,0.01039109],"genre_scores_gemma":[0.9844812,0.0112489,0.001358021,0.0001325975,0.00004125856,0.00002661001,0.00024884,0.00001364482,0.002448837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162541,"threshold_uncertainty_score":0.004363775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992360517203414,"score_gpt":0.3068430765383842,"score_spread":0.27691947136635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}