{"id":"W2539908888","doi":"10.1016/s1470-2045(16)30525-3","title":"Biochemical and imaging surveillance in Li-Fraumeni syndrome – Authors’ reply","year":2016,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Observational study; Medicine; Li–Fraumeni syndrome; Germline mutation; Internal medicine; Mutation; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002890319,0.0006302681,0.001817177,0.0009098913,0.002015522,0.003113241,0.001512706,0.04771665,0.00483559],"category_scores_gemma":[0.03011448,0.0008205403,0.001087949,0.0007208206,0.002653278,0.003629842,0.001848221,0.03915317,0.003700076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002339083,"about_ca_system_score_gemma":0.002452936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002830841,"about_ca_topic_score_gemma":0.003961534,"domain_scores_codex":[0.9975972,0.0008175634,0.0003791508,0.0003287871,0.0005322007,0.0003451335],"domain_scores_gemma":[0.9890084,0.006846254,0.0008557834,0.000345259,0.001618653,0.001325626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008215004,0.00002719564,0.001920003,0.0000775942,0.00003504259,0.003679037,0.0001727413,0.00009547573,0.0001731286,0.001604208,0.9849896,0.007143744],"study_design_scores_gemma":[0.0003346539,0.0001595442,0.003171833,0.0007310032,0.0001207896,0.0116425,0.001039664,0.000864445,0.0005211399,0.0147582,0.9664247,0.0002315201],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003409796,0.001682443,0.0000489683,0.9789342,0.01818311,0.000004915918,0.00005245466,0.00001290373,0.0007399163],"genre_scores_gemma":[0.005818989,0.001606914,0.0001576648,0.9286348,0.06121288,0.00002786281,0.00004538308,0.00001997227,0.00247563],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04771665,"threshold_uncertainty_score":0.01697129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532850457482967,"score_gpt":0.3030614810586907,"score_spread":0.2777329764838611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}