{"id":"W2540550614","doi":"10.15252/emmm.201606230","title":"Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy","year":2016,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Institut National de la Santé et de la Recherche Médicale; Fondation de l'Avenir pour la Recherche Médicale Appliquée","keywords":"Ototoxicity; Cisplatin; Hair cell; Chemotherapy; Inner ear; Pharmacology; Medicine; Apoptosis; Hearing loss; Cancer research; Internal medicine; Chemistry; Audiology; Anatomy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005189143,0.0003032873,0.0003654019,0.0001974716,0.0001525922,0.0000215139,0.0003068963,0.0001437402,0.0003615779],"category_scores_gemma":[0.001693685,0.0002269435,0.00008318855,0.0005037713,0.000256434,0.0001020131,0.0001474327,0.0002491307,0.0001870559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249366,"about_ca_system_score_gemma":0.00008144998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001924083,"about_ca_topic_score_gemma":0.000002278941,"domain_scores_codex":[0.9971407,0.0002731858,0.0004700087,0.0007222769,0.0008246785,0.000569171],"domain_scores_gemma":[0.9985929,0.0001868056,0.0002173279,0.0006886368,0.00006717428,0.0002471506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004116671,0.00008640686,0.0005010872,0.00003343241,0.0000105832,0.00006395388,0.0002848535,0.00001240922,0.9910799,0.0001848998,0.0003812397,0.007320017],"study_design_scores_gemma":[0.003011191,0.0002806767,0.002046361,0.000768151,0.00004850562,0.00007031126,0.00002034099,0.0002465745,0.98829,0.0006393418,0.004288896,0.0002897009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710757,0.0001092161,0.02019161,0.00358618,0.000276526,0.0006961801,0.000003712426,0.0001768943,0.003883943],"genre_scores_gemma":[0.9925861,0.00006201699,0.0008844045,0.00475842,0.0002133284,0.000017607,0.000002569356,0.00007101795,0.001404573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02151032,"threshold_uncertainty_score":0.9254488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03551424638767535,"score_gpt":0.3014476789896098,"score_spread":0.2659334326019344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}