{"id":"W2540550614","doi":"10.15252/emmm.201606230","title":"Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy","year":2016,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; Institut National de la Santé et de la Recherche Médicale; Fondation de l'Avenir pour la Recherche Médicale Appliquée","keywords":"Ototoxicity; Cisplatin; Hair cell; Chemotherapy; Inner ear; Pharmacology; Medicine; Apoptosis; Hearing loss; Cancer research; Internal medicine; Chemistry; Audiology; Anatomy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317158,0.0003173254,0.0003909749,0.0002762596,0.0001306075,0.0002378933,0.0003404725,0.000261502,0.001749844],"category_scores_gemma":[0.000210556,0.00013612,0.000208407,0.0001428742,0.0004085219,0.0002599635,0.0002437622,0.0008317454,0.0003525587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702439,"about_ca_system_score_gemma":0.0003069912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003934436,"about_ca_topic_score_gemma":0.0007836068,"domain_scores_codex":[0.9998422,0.0000221888,0.00001679797,0.00003279774,0.00004042378,0.00004561277],"domain_scores_gemma":[0.9999038,0.00002020418,0.0000226372,0.00001924634,0.00001000358,0.00002414023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002313029,0.00008624706,0.0001053831,0.00004623963,0.000007751597,0.00008392188,0.0000148352,0.0001065925,0.9955001,0.0002088333,0.000093405,0.003515376],"study_design_scores_gemma":[0.00005945583,0.001068505,0.001679662,0.000008594955,0.00002456335,0.0002226647,0.00001699362,0.000742545,0.9937779,0.000124842,0.002268751,0.000005544734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99136,0.002123645,0.003663719,0.0001484522,0.0000868877,0.00006129934,0.0001837007,0.000224303,0.002147882],"genre_scores_gemma":[0.9963765,0.001251728,0.001103106,0.00003672258,0.00001326686,0.00003778656,0.0001381262,0.00002179342,0.001021003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749844,"threshold_uncertainty_score":0.005853832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03551424638767535,"score_gpt":0.3014476789896098,"score_spread":0.2659334326019344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}