{"id":"W2540613192","doi":"10.1001/jamaoncol.2016.4877","title":"Systemic Therapy for Previously Untreated Advanced <i>BRAF</i>-Mutated Melanoma","year":2016,"lang":"en","type":"review","venue":"JAMA Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"","keywords":"Medicine; Hazard ratio; Oncology; Internal medicine; Melanoma; Randomized controlled trial; Meta-analysis; Odds ratio; Confidence interval; Adverse effect; MEK inhibitor; Progression-free survival; Overall survival; Cancer research; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01064967,0.0009750605,0.006457215,0.002246371,0.0002610293,0.002238083,0.0008628565,0.00167695,0.004239145],"category_scores_gemma":[0.03772457,0.0004234585,0.007275024,0.002168117,0.0006008366,0.00142755,0.0005091208,0.001777189,0.0003384087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001626809,"about_ca_system_score_gemma":0.002527953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002382464,"about_ca_topic_score_gemma":0.004886287,"domain_scores_codex":[0.9898828,0.005992587,0.002376122,0.0005981555,0.001024851,0.0001255738],"domain_scores_gemma":[0.9620815,0.03016008,0.006005092,0.0003867671,0.001150509,0.0002159977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006304733,0.0001140032,0.002153764,0.7904836,0.06015549,0.0001221378,0.00009728602,0.000482193,0.0006653431,0.000663262,0.004377108,0.1343811],"study_design_scores_gemma":[0.02315604,0.006349016,0.01263329,0.5759154,0.3350888,0.0006807733,0.0003227634,0.001220586,0.00151565,0.003897748,0.03910962,0.00011028],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003565024,0.9926096,0.0004404268,0.0009626161,0.0003836517,0.0005138162,0.0004474485,0.00001544009,0.00106194],"genre_scores_gemma":[0.1266354,0.8632406,0.003228371,0.003131457,0.001230555,0.001459044,0.0005274782,0.00001763724,0.0005294266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01064967,"threshold_uncertainty_score":0.0563215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02816477328477322,"score_gpt":0.3337088176855344,"score_spread":0.3055440444007612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}