{"id":"W2540786849","doi":"10.1158/2159-8290.cd-15-1263","title":"The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":444,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Prostate cancer; Androgen receptor; Cancer research; Neuroendocrine differentiation; Transcription factor; SOX2; Prostate; Enzalutamide; In vivo; Tramp; Biology; Cancer; Medicine; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004182369,0.0001801072,0.0002506873,0.00008787528,0.00006717497,0.00004492725,0.0001194731,0.00002964988,0.0003913513],"category_scores_gemma":[0.000009083506,0.00009002392,0.00009461215,0.0001662302,0.0001310887,0.0006343285,0.00002894571,0.0001217334,0.000003801602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003036477,"about_ca_system_score_gemma":0.0001807289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004552068,"about_ca_topic_score_gemma":0.0005077947,"domain_scores_codex":[0.9986002,0.00007854724,0.0002841284,0.0003329414,0.0003298482,0.0003743604],"domain_scores_gemma":[0.9993795,0.00004249573,0.00009792935,0.0002882613,0.00009224627,0.00009957774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00242134,0.0001345411,0.4936869,0.0001179279,0.00009570634,0.00001287035,0.0008145703,0.000006346564,0.464903,0.00001003659,0.0007320687,0.03706475],"study_design_scores_gemma":[0.006601629,0.0004448193,0.5012792,0.0003994041,0.00008558805,0.000003956597,0.0001636377,0.0001630101,0.4865427,0.00006352748,0.0040604,0.0001921357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884036,0.002449283,0.00001831637,0.007313601,0.0004254202,0.0007560201,0.0005822463,0.00001935449,0.00003214472],"genre_scores_gemma":[0.9826283,0.009840219,0.000003645984,0.0001537153,0.0001295983,0.0002816126,0.00004243617,0.00003044947,0.006890007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03687261,"threshold_uncertainty_score":0.4285023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03884735603184115,"score_gpt":0.3067152536351832,"score_spread":0.2678678976033421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}