{"id":"W2540806667","doi":"10.1371/journal.pbio.1002570","title":"Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials","year":2016,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; National Center for Complementary and Integrative Health; Northwestern University; Eli Lilly and Company","keywords":"Placebo; Duloxetine; Medicine; Placebo response; Functional magnetic resonance imaging; Clinical trial; Nocebo; Chronic pain; Internal medicine; Physical therapy; Pathology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1159539,0.0002288774,0.0006701951,0.0000830358,0.0001552554,0.00003298203,0.0004907667,0.0003088786,0.0003112741],"category_scores_gemma":[0.3849275,0.0001404712,0.0002240992,0.0001846576,0.0005469644,0.0001180362,0.000238523,0.000228577,0.0006925401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009268019,"about_ca_system_score_gemma":0.0001073882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004898948,"about_ca_topic_score_gemma":0.00002280452,"domain_scores_codex":[0.8828802,0.1143887,0.000793389,0.0009728721,0.0001707318,0.0007941382],"domain_scores_gemma":[0.7873765,0.2117536,0.0002716107,0.000452664,0.00001897141,0.0001267502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006210872,0.0001412241,0.01211074,0.00001917524,0.00004342636,0.00002997223,0.00005158563,7.495752e-7,0.8737065,0.0007447898,0.007878813,0.09906222],"study_design_scores_gemma":[0.02088975,0.006326256,0.01593743,0.0002840168,0.0001034576,0.00001888703,0.00003583936,0.008265488,0.4984745,0.006677078,0.4416853,0.001302027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727048,0.00005969585,0.01489637,0.009401556,0.0007498311,0.001217221,0.0001628031,0.0003028729,0.000504806],"genre_scores_gemma":[0.9946666,0.00007089902,0.00002773232,0.003079136,0.0005620476,0.0001233802,0.000004062375,0.00002064569,0.001445449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4338064,"threshold_uncertainty_score":0.9103115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1905264983237872,"score_gpt":0.4365516417375102,"score_spread":0.246025143413723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}