{"id":"W2541185728","doi":"10.1371/journal.pgen.1006405","title":"Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Filamentation; Biology; Candida albicans; Cell biology; Virulence; Genetics; Mutant; Protein kinase C; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001062366,0.0003206778,0.0001844802,0.0003273586,0.0001894096,0.0004250132,0.0002508113,0.0001976511,0.0004369519],"category_scores_gemma":[0.0001082157,0.0001595517,0.0001905519,0.0001938953,0.000176115,0.0001553096,0.0001869584,0.0004381177,0.0003739694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617091,"about_ca_system_score_gemma":0.0003294308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204335,"about_ca_topic_score_gemma":0.001682263,"domain_scores_codex":[0.9998259,0.00001719282,0.00001239274,0.00003094667,0.00005814732,0.00005540065],"domain_scores_gemma":[0.999907,0.000008926199,0.00003242512,0.00001145898,0.00001310832,0.00002707219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005467193,0.000008883389,0.0004163235,0.000008766775,9.101786e-7,0.00002664131,0.000005869501,0.00004761876,0.9987679,0.00005907224,0.00001904564,0.0005842355],"study_design_scores_gemma":[0.00001362888,0.00009434958,0.03278994,0.000007308141,0.0000159403,0.0003005609,0.00005803547,0.00213399,0.9632578,0.00009824201,0.00121978,0.00001030652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977126,0.0004689622,0.0005438167,0.00006510026,0.000005429506,0.00001005292,0.000281562,0.00004780945,0.0008645382],"genre_scores_gemma":[0.9969878,0.0004827125,0.0008946165,0.00002892503,0.000003958599,0.00001873293,0.0004656992,0.0000142525,0.00110337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204335,"threshold_uncertainty_score":0.00334996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035053479965271,"score_gpt":0.2865187028241439,"score_spread":0.251465222858873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}