{"id":"W2541674337","doi":"10.1146/annurev-pharmtox-010716-104651","title":"GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer","year":2016,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"GPER; Biology; Estrogen receptor; Receptor; Cell growth; Signal transduction; Cancer research; Cell biology; Endocrinology; Cancer; Breast cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238258,0.0006688256,0.0009457235,0.001318767,0.0002410201,0.0007151368,0.0005886716,0.0008924094,0.004302295],"category_scores_gemma":[0.0002848942,0.000165728,0.0003572914,0.001452518,0.000347361,0.0009812139,0.0005914349,0.001318382,0.00370537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004381243,"about_ca_system_score_gemma":0.0008206383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303423,"about_ca_topic_score_gemma":0.0008835117,"domain_scores_codex":[0.9999067,0.00001298692,0.00001094811,0.00002062114,0.00003452271,0.00001416812],"domain_scores_gemma":[0.9999213,0.00002560675,0.0000128831,0.0000029664,0.00002374165,0.00001345212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007423188,0.00004447306,0.0002532399,0.009049296,0.0000571453,0.0003525914,0.00007334468,0.000316201,0.00718523,0.006922064,0.05594999,0.9197222],"study_design_scores_gemma":[0.000006695528,0.00004535434,0.0005003713,0.0005422523,0.00003294526,0.001287716,0.00003660489,0.0000430025,0.0004156012,0.001086771,0.9959926,0.00001021472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004691502,0.9937668,0.0004417178,0.0007249314,0.0004604037,0.00001005713,0.00007391811,0.00003712578,0.004015835],"genre_scores_gemma":[0.001495639,0.995261,0.0003028763,0.0004027233,0.0002110563,0.00001003347,0.0001102879,0.000003493293,0.002202792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004302295,"threshold_uncertainty_score":0.01439261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729970855016464,"score_gpt":0.3440624785020359,"score_spread":0.3267627699518712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}