{"id":"W2541771697","doi":"10.1093/nar/gkw966","title":"Reciprocal regulation of chromatin state and architecture by<i>HOTAIRM1</i>contributes to temporal collinear<i>HOXA</i>gene activation","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Chromatin; Biology; Bivalent chromatin; Demethylase; PRC2; Histone; Gene silencing; Gene; Transcription (linguistics); Regulation of gene expression; Cell biology; Epigenetics; Genetics; Chromatin remodeling; Computational biology; Histone H3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763719,0.0002010582,0.0001576724,0.0001553782,0.0001835497,0.0004355915,0.0001657273,0.0001565012,0.001241105],"category_scores_gemma":[0.0001818358,0.0001909455,0.000272899,0.0001162823,0.0002791537,0.0002169332,0.0004313368,0.0003220451,0.0004364648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509857,"about_ca_system_score_gemma":0.0001316309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002966554,"about_ca_topic_score_gemma":0.000666967,"domain_scores_codex":[0.9998325,0.00002056677,0.00001155677,0.00006249444,0.00003346043,0.00003936944],"domain_scores_gemma":[0.9998164,0.00002596086,0.00007386045,0.00003005281,0.00001599021,0.00003775461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006292332,0.000005491518,0.001963438,0.00001695974,0.000006618895,0.00002971848,0.00001450485,0.00004960811,0.9964252,0.0001165039,0.00002528041,0.001283633],"study_design_scores_gemma":[0.000008325778,0.0001240473,0.07704583,0.000005287521,0.00002344879,0.0005313589,0.00005457188,0.001476034,0.9183386,0.0001755521,0.002207384,0.000009610855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922878,0.001366489,0.004633162,0.00007717551,0.00001856288,0.00001232965,0.0002018676,0.00009711351,0.001305589],"genre_scores_gemma":[0.9976364,0.0002324973,0.001166545,0.00002844049,0.000006059264,0.000007161319,0.0001900487,0.00001667175,0.0007161695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241105,"threshold_uncertainty_score":0.00415194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303227415078081,"score_gpt":0.2941315465899204,"score_spread":0.2810992724391396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}