{"id":"W2542049135","doi":"10.1161/circulationaha.116.023116","title":"Altered DNA Methylation of Long Noncoding RNA <i>H19</i> in Calcific Aortic Valve Disease Promotes Mineralization by Silencing <i>NOTCH1</i>","year":2016,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cégep de Chicoutimi; Université de Sherbrooke","funders":"","keywords":"Medicine; DNA methylation; Gene silencing; Long non-coding RNA; Methylation; Disease; Mineralization (soil science); Calcification; RNA; Cancer research; Cardiology; DNA; Pathology; Genetics; Gene; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422745,0.0002099852,0.0002114696,0.0002315621,0.0001592901,0.000222944,0.000149361,0.0002330678,0.001408709],"category_scores_gemma":[0.0001117689,0.0001321824,0.0002650218,0.0001130165,0.0002370372,0.000106678,0.0001504626,0.0003403297,0.0002390116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272729,"about_ca_system_score_gemma":0.0001285195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000582592,"about_ca_topic_score_gemma":0.0008358912,"domain_scores_codex":[0.9998846,0.00001088309,0.00001259803,0.00003872865,0.00002752608,0.0000256345],"domain_scores_gemma":[0.9998478,0.00002281329,0.0000619679,0.000009918724,0.00001358669,0.00004385232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001697244,0.00001620253,0.001745803,0.00002571541,0.00001130004,0.00006905125,0.0000153394,0.00002102326,0.9970073,0.0000241385,0.00003144546,0.0008630052],"study_design_scores_gemma":[0.00003631608,0.0004661144,0.07536343,0.000008813749,0.00007905887,0.0008008858,0.00007352103,0.0008451997,0.9202963,0.00008867281,0.001931995,0.00000970205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996282,0.001128208,0.001620481,0.00005599518,0.00002246174,0.00001190709,0.000240919,0.0000530443,0.0005849068],"genre_scores_gemma":[0.9974613,0.0003663326,0.0009248576,0.00005079465,0.00001169051,0.00001676532,0.0002943905,0.00001473333,0.000859109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408709,"threshold_uncertainty_score":0.004712582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758179575837223,"score_gpt":0.3082155499707647,"score_spread":0.2906337542123925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}