{"id":"W2542144042","doi":"10.1016/j.jaad.2016.08.053","title":"Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study","year":2016,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Windsor Clinical Research; Centre de Recherche Dermatologique du Québec Métropolitain; Innovaderm (Canada)","funders":"","keywords":"Medicine; Acne; Adverse effect; Gastroenterology; Randomized controlled trial; Internal medicine; Dosing; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001221502,0.001491201,0.003015987,0.0005464609,0.0004032729,0.001067695,0.0008199223,0.001248955,0.003858346],"category_scores_gemma":[0.000764583,0.0006539816,0.001511323,0.0005410771,0.001085593,0.001332771,0.0002818902,0.002309172,0.0005707575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005035712,"about_ca_system_score_gemma":0.000886964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136954,"about_ca_topic_score_gemma":0.002678951,"domain_scores_codex":[0.9995953,0.0001706407,0.00002637321,0.00006519294,0.00004367708,0.00009873382],"domain_scores_gemma":[0.9995882,0.0001141115,0.00008919224,0.00003122914,0.00003119211,0.0001459881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9324501,0.01593799,0.0009202951,0.001514893,0.001656132,0.00008405621,0.00008633766,0.0005019071,0.01110428,0.0001553614,0.0007703871,0.03481823],"study_design_scores_gemma":[0.8973328,0.09687062,0.002771477,0.00005117852,0.0009739283,0.00005069726,0.00005068474,0.0003858062,0.0007765444,0.00009036506,0.0006251372,0.00002077132],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808459,0.01321087,0.0009531124,0.0004006148,0.0003372405,0.001739746,0.000620621,0.0001183812,0.001773574],"genre_scores_gemma":[0.983813,0.009586412,0.001222722,0.0008031703,0.0003824426,0.00133215,0.0007108827,0.00002872467,0.002120431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003858346,"threshold_uncertainty_score":0.01290751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864578524104902,"score_gpt":0.3435109499730964,"score_spread":0.3248651647320474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}