{"id":"W2542459035","doi":"10.1002/path.4780","title":"A focused compound screen highlights the significance of epidermal growth factor receptor signalling in chordoma pathogenesis","year":2016,"lang":"en","type":"letter","venue":"The Journal of Pathology","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chordoma; Epidermal growth factor receptor; Medicine; EGFR inhibitors; Cancer research; Clinical significance; Pathological; Oncology; Internal medicine; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005758075,0.0004696881,0.000528597,0.0003570903,0.0006619974,0.001049975,0.0003895736,0.00539728,0.002769765],"category_scores_gemma":[0.003129433,0.0001610106,0.0003974927,0.0002741881,0.0007425376,0.000778876,0.0004144745,0.004156425,0.002372929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001125146,"about_ca_system_score_gemma":0.0004712633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860595,"about_ca_topic_score_gemma":0.001305902,"domain_scores_codex":[0.9995467,0.00009693648,0.00006866619,0.00005323548,0.0001589516,0.00007556019],"domain_scores_gemma":[0.9988856,0.000570422,0.00009840614,0.00005365527,0.0002181793,0.0001739029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0008520913,0.0003118,0.008433131,0.0007589604,0.00006010751,0.198039,0.000496993,0.001023495,0.0245218,0.01115222,0.5078862,0.2464642],"study_design_scores_gemma":[0.0003924472,0.001403026,0.005926847,0.0003594263,0.00009507169,0.2224198,0.0004019587,0.002559362,0.01193391,0.01286849,0.7415753,0.00006428959],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0745073,0.0420256,0.003754075,0.7994764,0.01621243,0.0001899867,0.0005406048,0.0004562463,0.06283746],"genre_scores_gemma":[0.5074376,0.05820311,0.005926964,0.3237274,0.05270678,0.0001623198,0.0004650151,0.00008642139,0.05128431],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00539728,"threshold_uncertainty_score":0.00926578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227890468316075,"score_gpt":0.2649627909131119,"score_spread":0.2326838862299511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}