{"id":"W2542466442","doi":"10.1681/asn.2016030337","title":"Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity","year":2016,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Institute of Genetics; National Natural Science Foundation of China; National Institutes of Health; Wayne State University; Inha University; National Key Research and Development Program of China; U.S. Department of Veterans Affairs","keywords":"Autophagy; Cisplatin; PI3K/AKT/mTOR pathway; Protein kinase B; Nephrotoxicity; Protein kinase C; Apoptosis; Cancer research; Chemistry; Phosphorylation; Kinase; Cell biology; Pharmacology; Biology; Kidney; Medicine; Biochemistry; Endocrinology; Internal medicine; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707202,0.0003920063,0.0005234173,0.0004053898,0.0001971719,0.0002246405,0.0003000585,0.0002420015,0.0008699822],"category_scores_gemma":[0.0001422995,0.0001854769,0.0004155554,0.0002841409,0.0002887297,0.0002382358,0.0002249028,0.001008476,0.0002161023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003777049,"about_ca_system_score_gemma":0.0006656306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006530729,"about_ca_topic_score_gemma":0.0009603145,"domain_scores_codex":[0.9998564,0.00001986451,0.00002649555,0.00002520473,0.00003660767,0.00003551374],"domain_scores_gemma":[0.9999329,0.000005721759,0.00001755177,0.00001250357,0.00001163274,0.00001966406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008038625,0.0001729778,0.0003653458,0.0002260885,0.000028147,0.0000939366,0.00002202001,0.0002858489,0.993422,0.0002600965,0.0001813926,0.004138253],"study_design_scores_gemma":[0.0001412808,0.0006423228,0.00385571,0.00001469567,0.0000465596,0.0003873082,0.00002742708,0.001757648,0.9899297,0.0001388672,0.003049209,0.000009202802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881732,0.005251354,0.003972808,0.0002555323,0.0001846309,0.0000965188,0.0002956798,0.0001771811,0.001593193],"genre_scores_gemma":[0.9943245,0.002298737,0.001572089,0.00008366568,0.00001545452,0.00007983237,0.0002743371,0.00001513095,0.00133634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008699822,"threshold_uncertainty_score":0.002910376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137717163454144,"score_gpt":0.268578266148167,"score_spread":0.2548065498027526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}