{"id":"W2542576093","doi":"10.1186/s13072-016-0086-0","title":"Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3","year":2016,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Transnationale Universiteit Limburg; René Vogels Stichting; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"H3K4me3; Biology; Epigenetics; Demethylase; Epigenomics; Histone; Histone methylation; Histone H3; Cell biology; Genetics; Gene expression; DNA methylation; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005606034,0.0004159402,0.0004179079,0.0001350072,0.0001227945,0.00003452142,0.0004980987,0.0002762037,0.0002418022],"category_scores_gemma":[0.0003175964,0.0003510601,0.000217066,0.000208342,0.0002555347,0.000006680656,0.0002540984,0.00008649873,0.00005979371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005713192,"about_ca_system_score_gemma":0.0001087981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000327838,"about_ca_topic_score_gemma":0.00001787919,"domain_scores_codex":[0.9970712,0.0002659828,0.0008880213,0.000741921,0.0004443176,0.0005885611],"domain_scores_gemma":[0.9979547,0.0001851837,0.0004337501,0.0009903682,0.0001942653,0.0002417783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004468566,0.0001714681,0.01956675,0.00004298037,0.00006925355,0.000002795257,0.0000402005,0.00007932416,0.9674364,0.00002522357,0.001496058,0.0110249],"study_design_scores_gemma":[0.0008102201,0.0004697236,0.06634284,0.00007395846,0.0000327733,0.000002515981,0.00002708294,0.00001793343,0.8679206,0.0003714375,0.06347273,0.0004581343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504935,0.01966932,0.02749291,0.0001647027,0.0001965299,0.0004202393,0.0001852825,0.00002839515,0.001349188],"genre_scores_gemma":[0.9813022,0.01189847,0.004988913,0.00007464653,0.0003115976,0.00004039711,0.0001914854,0.00009590427,0.001096365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09951571,"threshold_uncertainty_score":0.9998941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009925080786062059,"score_gpt":0.2267424517088279,"score_spread":0.2168173709227658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}