{"id":"W2542642374","doi":"10.1128/aac.00790-16","title":"Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepacia","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Cystic Fibrosis Canada","keywords":"Burkholderia cenocepacia; Biology; Microbiology; Novobiocin; Response regulator; Transposon mutagenesis; Efflux; Kanamycin; Mutant; Antibiotics; Transposable element; Gene; Genetics; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166112,0.000617421,0.000367702,0.0003220224,0.0001257869,0.0003658813,0.000240675,0.0002624432,0.0006430636],"category_scores_gemma":[0.0002608939,0.0002081233,0.0002337912,0.0002540827,0.0002406504,0.000201213,0.0004684406,0.0004809482,0.0003462184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936255,"about_ca_system_score_gemma":0.0002435101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083083,"about_ca_topic_score_gemma":0.001492023,"domain_scores_codex":[0.9996277,0.00005911007,0.00003437482,0.00007483851,0.0001364934,0.00006756133],"domain_scores_gemma":[0.9997523,0.00005825999,0.00006583772,0.00004267016,0.00003604851,0.00004497469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001012243,0.000005496017,0.00009683707,0.000005200658,7.783303e-7,0.00001102163,0.00000311154,0.00001390211,0.9996288,0.0000113916,0.000003153092,0.0002101661],"study_design_scores_gemma":[0.000004296953,0.0001185174,0.006040461,0.000002458051,0.000008200755,0.0001911533,0.0000251351,0.0008531806,0.9921674,0.00002955947,0.0005546764,0.000005017614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929314,0.0002871188,0.005649852,0.00008491483,0.000009169455,0.00002224069,0.0003609903,0.0001287728,0.0005255662],"genre_scores_gemma":[0.9935921,0.000202425,0.004226031,0.00005848963,0.000004184965,0.00003174154,0.0006280898,0.00005045498,0.001206463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083083,"threshold_uncertainty_score":0.002153516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120207329150603,"score_gpt":0.2863429338933149,"score_spread":0.2751408606018089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}