{"id":"W2542788745","doi":"10.1159/000447903","title":"Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation","year":2016,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"University Hospitals Coventry and Warwickshire NHS Trust; Eberhard Karls Universität Tübingen; Warwick Medical School; Deutsche Forschungsgemeinschaft; University of Warwick","keywords":"Protein kinase B; SGK1; PI3K/AKT/mTOR pathway; Phosphorylation; Cell biology; Ubiquitin ligase; Kinase; Endometrium; Chemistry; Biology; Endocrinology; Signal transduction; Ubiquitin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004843712,0.000137096,0.000275542,0.0001861575,0.00003411034,0.000002218553,0.00007056195,0.0003072344,0.00005611794],"category_scores_gemma":[0.0002333091,0.0001035177,0.00004496832,0.0002088129,0.0001443112,0.0000620521,0.00004897913,0.0001113175,0.00002983655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004250959,"about_ca_system_score_gemma":0.00004853349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003531286,"about_ca_topic_score_gemma":0.000001999785,"domain_scores_codex":[0.9986531,0.0003778826,0.0003364636,0.0003936232,0.00002544721,0.0002135276],"domain_scores_gemma":[0.9993055,0.0002900774,0.0001360864,0.0002062446,0.00004372266,0.00001831746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002999542,0.00008687771,0.001294214,0.00006551015,0.00001696329,0.000003522714,0.0002425142,0.000002101915,0.9941534,0.00001832747,0.00003779265,0.001079177],"study_design_scores_gemma":[0.002422017,0.0001951306,0.02961616,0.000157464,0.000005266027,0.00001130442,0.0001108866,1.044914e-7,0.9670402,0.0002553798,0.00006151786,0.0001245735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988305,0.0003542469,0.00007805126,0.0001062931,0.0002564213,0.0002481072,0.00006433688,0.00001134017,0.00005070492],"genre_scores_gemma":[0.9994611,0.00002741415,0.00001563894,0.00001606185,0.00006317718,0.00002670076,0.00007049954,0.000007227961,0.0003122533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02832194,"threshold_uncertainty_score":0.4221328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007421840665470053,"score_gpt":0.2188358254830729,"score_spread":0.2114139848176029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}