{"id":"W2542967618","doi":"10.1182/blood.v112.11.4008.4008","title":"Pharmacokinetic Results from a Phase 1 Study of a Multi-Targeted Tyrosine Kinase Inhibitor, ABT-869, in Patients with Refractory or Relapsed Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacokinetics; Internal medicine; Cohort; Pharmacodynamics; Dosing; Pharmacology; Oncology; Cmax; Tyrosine-kinase inhibitor; Gastroenterology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001171484,0.0007694608,0.001142634,0.0002889382,0.0003796409,0.0007808897,0.0004277692,0.0006798232,0.001222887],"category_scores_gemma":[0.001327372,0.000544685,0.0007057622,0.0003429894,0.0005191616,0.0006727586,0.00023954,0.001966104,0.0003758965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007675831,"about_ca_system_score_gemma":0.0008692299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005965062,"about_ca_topic_score_gemma":0.001199432,"domain_scores_codex":[0.9994469,0.0002811255,0.00002769161,0.0001057129,0.00007595569,0.00006259796],"domain_scores_gemma":[0.9993652,0.000158687,0.0001597107,0.00005482594,0.00003741198,0.0002241617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.379662,0.07170691,0.03842757,0.0005916376,0.001454478,0.0009522184,0.0008427439,0.01222055,0.3434523,0.0005590513,0.005411725,0.1447188],"study_design_scores_gemma":[0.1743004,0.6335025,0.13011,0.00004134302,0.001492833,0.002128052,0.0001555448,0.01193504,0.03773487,0.0005524576,0.007913929,0.0001331008],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968513,0.0005845107,0.0006202172,0.0001306808,0.00002309341,0.0004133705,0.0005636198,0.00004880717,0.0007644446],"genre_scores_gemma":[0.996394,0.0004154645,0.0009636004,0.0002253139,0.00004218667,0.0002260383,0.0009937144,0.00002093864,0.0007186895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222887,"threshold_uncertainty_score":0.006195486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110943362646991,"score_gpt":0.2692309816465821,"score_spread":0.2481215480201122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}