{"id":"W2543485777","doi":"10.1073/pnas.1615340113","title":"Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Canadian Institutes of Health Research; National Cancer Institute; Government of Canada; National Institutes of Health; National Institute of Neurological Disorders and Stroke; American Heart Association; California Institute for Regenerative Medicine","keywords":"Dystrophin; Telomere; Duchenne muscular dystrophy; Cardiomyopathy; Wasting; Heart failure; Muscular dystrophy; Skeletal muscle; Biology; Mitochondrial DNA; Oxidative stress; Mitochondrion; mdx mouse; Internal medicine; Cardiac muscle; Endocrinology; Medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125496,0.0004304461,0.0002334335,0.0004189239,0.0002157718,0.0001846366,0.0001502045,0.0004467645,0.001165015],"category_scores_gemma":[0.0001023733,0.0001750649,0.000238286,0.0001711792,0.0003273776,0.0001764333,0.0002588165,0.0004764314,0.0001405775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781145,"about_ca_system_score_gemma":0.0001389597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001966884,"about_ca_topic_score_gemma":0.0007203567,"domain_scores_codex":[0.9998956,0.00002274204,0.00001420311,0.00002713314,0.00002188291,0.00001846145],"domain_scores_gemma":[0.9999222,0.000009295207,0.00003811776,0.000007456589,0.000004045445,0.00001889716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002940798,0.00004980129,0.00101064,0.0000604668,0.00001682785,0.0005381874,0.00004021778,0.0001212611,0.9954624,0.0003622413,0.0000912011,0.001952716],"study_design_scores_gemma":[0.0001540437,0.002021348,0.05473276,0.0000949528,0.0001997152,0.01124616,0.000158426,0.003205964,0.9167894,0.001073662,0.01030138,0.00002231253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916761,0.002688631,0.003893497,0.0002268744,0.0000357393,0.00003119399,0.0003372291,0.00009470113,0.00101608],"genre_scores_gemma":[0.9945803,0.00161513,0.001757849,0.00008860662,0.0000171106,0.00004873859,0.0002615025,0.00001112596,0.001619574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165015,"threshold_uncertainty_score":0.003897309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04645648722631979,"score_gpt":0.2975247826845088,"score_spread":0.251068295458189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}