{"id":"W2544261095","doi":"10.1002/hep.28850","title":"Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; KMT Hepatech (Canada)","funders":"MPOWER Financing; National Institute of Allergy and Infectious Diseases","keywords":"Neutralization; Monoclonal antibody; Virology; Antibody; Hepatitis C virus; Epitope; Virus; Neutralizing antibody; Conformational epitope; Immunology; Potency; Medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003072931,0.0006185292,0.0002475322,0.0003783608,0.0001282137,0.0002936376,0.0003130157,0.0005254638,0.001836631],"category_scores_gemma":[0.0001485034,0.0002308395,0.0003173999,0.0001363506,0.0001734826,0.0002486332,0.0002029533,0.001154712,0.000961288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814988,"about_ca_system_score_gemma":0.0002893343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005350714,"about_ca_topic_score_gemma":0.000559247,"domain_scores_codex":[0.9998087,0.00002981447,0.00001409966,0.00004929711,0.00004661342,0.00005154944],"domain_scores_gemma":[0.9998773,0.00001013884,0.00003812903,0.00001592398,0.00002836375,0.00003006049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403213,0.00009769901,0.0001406911,0.0000282577,0.000009170163,0.00002267647,0.000007929579,0.0001020012,0.9952189,0.0001136502,0.0001797234,0.003938825],"study_design_scores_gemma":[0.0001481863,0.001794941,0.003045021,0.00001675377,0.00005377199,0.0003556639,0.00001200525,0.001970579,0.9856164,0.0001090485,0.006869305,0.000008304356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687554,0.003295351,0.01880669,0.0005107911,0.0001684884,0.0002750237,0.001055331,0.0005742677,0.00655875],"genre_scores_gemma":[0.9732856,0.001767321,0.01518598,0.0004352945,0.00004976861,0.0001358457,0.001161898,0.00007338137,0.007905043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001836631,"threshold_uncertainty_score":0.006144106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04834976604585428,"score_gpt":0.3780385816962191,"score_spread":0.3296888156503648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}