{"id":"W2544261095","doi":"10.1002/hep.28850","title":"Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; KMT Hepatech (Canada)","funders":"MPOWER Financing; National Institute of Allergy and Infectious Diseases","keywords":"Neutralization; Monoclonal antibody; Virology; Antibody; Hepatitis C virus; Epitope; Virus; Neutralizing antibody; Conformational epitope; Immunology; Potency; Medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912761,0.0001664118,0.000465718,0.0003873597,0.00006323318,0.000009343374,0.0001011058,0.0002473315,0.0002977725],"category_scores_gemma":[0.0001341377,0.0001354902,0.00009596997,0.0002729368,0.0001459921,0.0002486396,0.0000811613,0.0002474787,0.00007862423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032396,"about_ca_system_score_gemma":0.0001414962,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01913207,"about_ca_topic_score_gemma":0.01783678,"domain_scores_codex":[0.9981966,0.0003178169,0.0004519849,0.0003358214,0.0002967645,0.0004009859],"domain_scores_gemma":[0.9992182,0.0001245888,0.0001684043,0.0002645874,0.000113244,0.0001109435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001757246,0.0001459284,0.6851262,0.00005932433,0.00005761892,0.0001058487,0.00008525027,3.036254e-7,0.3108805,0.0002182396,0.0001729783,0.002972046],"study_design_scores_gemma":[0.001679347,0.0003928789,0.8624628,0.0002020757,0.00005078775,0.0001127268,0.000002301375,0.000267828,0.133517,0.000330582,0.0008459585,0.0001357477],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972323,0.00006357457,0.0004307973,0.0005086098,0.0001686107,0.0004845263,0.00004255345,0.00005324966,0.001015731],"genre_scores_gemma":[0.9971596,0.002032981,0.0002933613,0.0001309521,0.00005479837,0.00004941195,0.00006852762,0.00002635719,0.0001840225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1773635,"threshold_uncertainty_score":0.9953344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04834976604585428,"score_gpt":0.3780385816962191,"score_spread":0.3296888156503648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}