{"id":"W2544444843","doi":"10.1016/j.jval.2016.09.1074","title":"Results of A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of The Efficacy And Safety of Sirukumab, An Anti-IL-6 Cytokine Monoclonal Antibody, In Patients with Active Rheumatoid Arthritis Despite Disease-Modifying Anti-Rheumatic Drug Treatment (Sirround-D)","year":2016,"lang":"en","type":"article","venue":"Value in Health","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Southlake Regional Health Center","funders":"","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Rheumatology; Clinical endpoint; Adverse effect; Randomized controlled trial; Monoclonal antibody; Gastroenterology; Antibody; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005568135,0.002452855,0.005076628,0.0007336228,0.001153644,0.001324829,0.00125377,0.003672598,0.006044625],"category_scores_gemma":[0.004661433,0.001186388,0.003349377,0.000592529,0.00231734,0.001988523,0.000492329,0.00529121,0.001136372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008543525,"about_ca_system_score_gemma":0.002062703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199876,"about_ca_topic_score_gemma":0.002439856,"domain_scores_codex":[0.9981925,0.0009222218,0.0001766761,0.0003189801,0.0001696027,0.0002200895],"domain_scores_gemma":[0.9965246,0.001445368,0.0006222611,0.0003045607,0.0002961835,0.000807024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9805131,0.008329771,0.0003873967,0.0004131024,0.001031094,0.00003310539,0.00005944848,0.0001452549,0.002338247,0.00005547733,0.000463685,0.006230427],"study_design_scores_gemma":[0.9639385,0.03363708,0.001226418,0.0000153141,0.0004904079,0.00001663115,0.00001047382,0.00008708439,0.0002771974,0.00007126205,0.0002173968,0.00001229802],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616619,0.01107499,0.002775083,0.001360257,0.001283866,0.01270939,0.003936315,0.000382455,0.004815658],"genre_scores_gemma":[0.975114,0.004022675,0.004081143,0.003092313,0.0009490937,0.007157334,0.002817427,0.00009717022,0.002668878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006044625,"threshold_uncertainty_score":0.02944744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893995812731497,"score_gpt":0.3266549871393329,"score_spread":0.2977150290120179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}