{"id":"W2544444843","doi":"10.1016/j.jval.2016.09.1074","title":"Results of A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of The Efficacy And Safety of Sirukumab, An Anti-IL-6 Cytokine Monoclonal Antibody, In Patients with Active Rheumatoid Arthritis Despite Disease-Modifying Anti-Rheumatic Drug Treatment (Sirround-D)","year":2016,"lang":"en","type":"article","venue":"Value in Health","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Southlake Regional Health Center","funders":"","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Rheumatology; Clinical endpoint; Adverse effect; Randomized controlled trial; Monoclonal antibody; Gastroenterology; Antibody; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002235807,0.0003731048,0.002551871,0.0005334616,0.00013107,0.00001732115,0.0001857532,0.00005955228,0.0000083404],"category_scores_gemma":[0.0005884848,0.0001988621,0.0001629688,0.0004826953,0.000498002,0.0002696891,0.00007090245,0.0001980946,5.332823e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163748,"about_ca_system_score_gemma":0.0007263967,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0067996,"about_ca_topic_score_gemma":0.000660571,"domain_scores_codex":[0.9942505,0.001703499,0.002064141,0.0005353283,0.0009025201,0.0005439546],"domain_scores_gemma":[0.9959142,0.001762963,0.001080365,0.0006629446,0.0002458706,0.0003336513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8563076,0.0117342,0.1056097,0.0002435997,0.0004579654,0.00001562795,0.007457347,0.0003021476,0.000276252,0.00008577721,7.773023e-7,0.01750905],"study_design_scores_gemma":[0.8522336,0.005075475,0.1338259,0.006641112,0.00002206581,0.00000632613,0.0007299887,0.0008490465,0.0003966676,0.00005981565,0.000003352067,0.0001566448],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852585,0.002290949,0.00003084278,0.0003842416,0.00005222956,0.01166223,0.0002924852,0.00001738606,0.00001109333],"genre_scores_gemma":[0.9779893,0.02159696,0.0001045853,0.000009017503,0.000009014962,0.0002039135,0.00004294536,0.00003841285,0.000005812293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02821625,"threshold_uncertainty_score":0.9998142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893995812731497,"score_gpt":0.3266549871393329,"score_spread":0.2977150290120179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}