{"id":"W2544600340","doi":"10.1182/blood.v120.21.1517.1517","title":"Interim Report of a Randomized, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of Decitabine As an Epigenetic Priming Agent When Combined with Induction Chemotherapy in Pediatric Patients (pts) with Newly Diagnosed Acute Myelogenous Leukemia (AML)","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"","keywords":"Decitabine; Medicine; Cytarabine; Internal medicine; Oncology; Etoposide; Azacitidine; Induction chemotherapy; Leukemia; Idarubicin; Daunorubicin; Chemotherapy regimen; Chemotherapy; Surgery; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003513144,0.001292915,0.002244511,0.0002242936,0.0004682908,0.0008021226,0.000713406,0.001447465,0.004641024],"category_scores_gemma":[0.002094716,0.0005877522,0.001070453,0.0002865534,0.0009681775,0.0009089902,0.000334778,0.002538894,0.0008378098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000597997,"about_ca_system_score_gemma":0.002057188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502309,"about_ca_topic_score_gemma":0.0008216383,"domain_scores_codex":[0.9987172,0.0008020009,0.00008463772,0.0001590365,0.0000765407,0.0001605809],"domain_scores_gemma":[0.9977482,0.0005898079,0.0005432663,0.0002536599,0.0001448715,0.0007201057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9590359,0.01472767,0.002807626,0.0002217328,0.0006919986,0.0000651072,0.00005100677,0.0003177291,0.006291328,0.00008139043,0.0008916582,0.01481688],"study_design_scores_gemma":[0.7259469,0.265394,0.004857244,0.00002170059,0.0004773955,0.00006327438,0.00001920386,0.000360148,0.001607156,0.00008618036,0.001155686,0.00001116857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872399,0.001507315,0.0009750874,0.0005607669,0.0003265433,0.006228365,0.001815993,0.00007970648,0.001266305],"genre_scores_gemma":[0.9821317,0.001193782,0.003044689,0.001056111,0.0005361896,0.007686386,0.002275707,0.00003724538,0.002038105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004641024,"threshold_uncertainty_score":0.01857948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733845902914791,"score_gpt":0.322284079577052,"score_spread":0.2949456205479041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}