{"id":"W2544627141","doi":"10.1016/j.lungcan.2016.10.011","title":"Nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with relapsed or refractory, advanced non-small cell lung cancer (LUME-Lung 2): A randomized, double-blind, phase III trial","year":2016,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Boehringer Ingelheim (Canada)","funders":"","keywords":"Pemetrexed; Medicine; Nintedanib; Internal medicine; Lung cancer; Hazard ratio; Placebo; Clinical endpoint; Oncology; Bevacizumab; Gastroenterology; Chemotherapy; Surgery; Randomized controlled trial; Confidence interval; Lung; Idiopathic pulmonary fibrosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004350643,0.0008850746,0.002049758,0.0006366335,0.0002378641,0.00006972992,0.0003364536,0.0003369592,0.001956149],"category_scores_gemma":[0.0001862114,0.0005321265,0.0003985378,0.001081436,0.0002134762,0.0005106374,0.00009992493,0.000542357,0.00001721912],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006582998,"about_ca_system_score_gemma":0.003516696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004556204,"about_ca_topic_score_gemma":0.005819619,"domain_scores_codex":[0.9951469,0.0002023445,0.001228384,0.001293254,0.0009987602,0.001130328],"domain_scores_gemma":[0.9963956,0.0007477094,0.0008394782,0.0008968005,0.0005832249,0.000537133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9787383,0.00126733,0.005004304,0.000347928,0.002161305,0.000103421,0.002036108,0.0003321663,0.0002146505,0.00001426826,0.003592357,0.006187828],"study_design_scores_gemma":[0.9845324,0.002291458,0.0005540967,0.001950771,0.004903915,0.000001971387,0.0002682986,0.002173174,0.0007990851,0.000001552933,0.001730748,0.0007924984],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683908,0.004561143,0.001155256,0.0006685322,0.003833828,0.01735032,0.0003219633,0.0002081012,0.003510011],"genre_scores_gemma":[0.9674566,0.001346603,0.0006729428,0.0002536439,0.0007032523,0.009671536,0.0002835212,0.0002298836,0.01938197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01587196,"threshold_uncertainty_score":0.999713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024304551739279,"score_gpt":0.3488162317950362,"score_spread":0.3285731862776434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}