{"id":"W2544627141","doi":"10.1016/j.lungcan.2016.10.011","title":"Nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with relapsed or refractory, advanced non-small cell lung cancer (LUME-Lung 2): A randomized, double-blind, phase III trial","year":2016,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Boehringer Ingelheim (Canada)","funders":"","keywords":"Pemetrexed; Medicine; Nintedanib; Internal medicine; Lung cancer; Hazard ratio; Placebo; Clinical endpoint; Oncology; Bevacizumab; Gastroenterology; Chemotherapy; Surgery; Randomized controlled trial; Confidence interval; Lung; Idiopathic pulmonary fibrosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378355,0.001915684,0.003597636,0.0004071273,0.0004352257,0.0009530653,0.001106948,0.001621738,0.006052095],"category_scores_gemma":[0.001188001,0.0007784134,0.001692227,0.000362999,0.001249514,0.001362613,0.0004050993,0.00314333,0.001175932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007037572,"about_ca_system_score_gemma":0.0009842316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058225,"about_ca_topic_score_gemma":0.002404376,"domain_scores_codex":[0.9995965,0.0001927289,0.00002358484,0.00008792429,0.00002598705,0.00007320069],"domain_scores_gemma":[0.9994906,0.0001407288,0.00009097721,0.00003794557,0.0000285836,0.0002110605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9833356,0.004150874,0.0002176741,0.0004754447,0.0005703877,0.0000223344,0.00003369164,0.0002711989,0.001829768,0.00007320166,0.0004448143,0.008574977],"study_design_scores_gemma":[0.9596024,0.03878259,0.0005691602,0.00001580162,0.0002270888,0.00001521091,0.00001504035,0.0002627101,0.0001933295,0.00007081158,0.0002375491,0.000008295241],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856448,0.0059689,0.0006621329,0.0008883238,0.0009863222,0.002788106,0.0009278904,0.0001756954,0.001957926],"genre_scores_gemma":[0.9847527,0.0038431,0.001333286,0.000965977,0.000451321,0.002924456,0.0009415237,0.00002944284,0.004758168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006052095,"threshold_uncertainty_score":0.02024633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024304551739279,"score_gpt":0.3488162317950362,"score_spread":0.3285731862776434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}