{"id":"W2545245817","doi":"10.1038/nature19479","title":"Bad neighbours cause bad blood","year":2016,"lang":"en","type":"letter","venue":"Nature","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Haematopoiesis; PTPN11; Bone marrow; Cancer research; Biology; Carcinogenesis; Cancer; Stem cell; Immunology; Gain of function; Protein tyrosine phosphatase; Mutation; Receptor; Genetics; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001380806,0.0006817328,0.001019219,0.0005204213,0.002973729,0.002777172,0.0009561672,0.02742787,0.009039275],"category_scores_gemma":[0.01338909,0.0005065526,0.0007561615,0.000390459,0.002730345,0.002422861,0.001372935,0.02819128,0.004859231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002250468,"about_ca_system_score_gemma":0.001286503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002151626,"about_ca_topic_score_gemma":0.003722779,"domain_scores_codex":[0.9988115,0.0003569833,0.00008317016,0.0001856906,0.0003558114,0.000206805],"domain_scores_gemma":[0.9976977,0.00118794,0.0001795741,0.0001333463,0.0002117389,0.0005897521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001543932,0.00003976862,0.001003576,0.00005187315,0.00005163195,0.004375243,0.00009782757,0.00005158092,0.0002529208,0.0103415,0.9705546,0.01302507],"study_design_scores_gemma":[0.0004165622,0.0001122517,0.002560492,0.0002528308,0.0001077317,0.009589487,0.000396737,0.0006333149,0.0006068205,0.05038522,0.9348615,0.00007685575],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0009925478,0.005004055,0.0001519231,0.9490023,0.03571752,0.00000986909,0.00006402338,0.00004359383,0.009014179],"genre_scores_gemma":[0.02752193,0.004620594,0.0002363446,0.8516973,0.08058189,0.00004384612,0.00006301546,0.00004009183,0.0351951],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02742787,"threshold_uncertainty_score":0.0302394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00524501622525312,"score_gpt":0.241292497244454,"score_spread":0.2360474810192009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}