{"id":"W2545779875","doi":"10.1007/s40291-016-0238-8","title":"Economic Evaluation of a Pharmacogenomics Test for Statin-Induced Myopathy in Cardiovascular High-Risk Patients Initiating a Statin","year":2016,"lang":"en","type":"article","venue":"Molecular Diagnosis & Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Université de Montréal; Programs for Assessment of Technology in Health Research Institute; Centre Hospitalier de l’Université de Montréal","funders":"Pfizer Canada; Génome Québec; Genome Canada; Pfizer","keywords":"Pharmacogenomics; Statin; Medicine; Myopathy; Internal medicine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Test (biology); Rhabdomyolysis; Atorvastatin; Intensive care medicine; Cardiology; Physical therapy; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01450331,0.001128679,0.001609262,0.0009476679,0.0004603963,0.002249157,0.001731708,0.002650697,0.006792074],"category_scores_gemma":[0.0572232,0.0006667068,0.002294041,0.0007552753,0.001027733,0.001607716,0.001345256,0.002003681,0.0002338217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007214158,"about_ca_system_score_gemma":0.005355983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01146297,"about_ca_topic_score_gemma":0.004820474,"domain_scores_codex":[0.9907746,0.007472056,0.0002198481,0.0004306131,0.0005059568,0.0005969239],"domain_scores_gemma":[0.9311733,0.06269791,0.002826845,0.0008134235,0.001196175,0.001292275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.006092145,0.0007516491,0.01505022,0.0004667759,0.0008364677,0.0002961012,0.00004474234,0.9489208,0.0003589785,0.01173798,0.001088377,0.0143557],"study_design_scores_gemma":[0.001430709,0.003430476,0.008114644,0.0002329924,0.001253455,0.0002312893,0.000109884,0.973751,0.000542718,0.009874209,0.0009614843,0.00006704521],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8991818,0.003837858,0.06286784,0.008830333,0.000232001,0.001889991,0.003181047,0.0001616175,0.01981762],"genre_scores_gemma":[0.9953556,0.0002847427,0.003192124,0.0002158866,0.00002085388,0.0001450669,0.0002245487,0.000004966323,0.0005561569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01450331,"threshold_uncertainty_score":0.07670176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888841877277417,"score_gpt":0.299047655194667,"score_spread":0.2701592364218928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}