{"id":"W2545908345","doi":"10.1038/ncomms13171","title":"Mitochondrial function controls intestinal epithelial stemness and proliferation","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Deutsche Forschungsgemeinschaft","keywords":"Biology; Stem cell; Cell biology; Wnt signaling pathway; Paracrine signalling; Intestinal epithelium; HSP60; Epithelium; Cancer research; Heat shock protein; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032244,0.0001881012,0.0001338178,0.0002187437,0.0001251633,0.0003674038,0.000122705,0.000196367,0.0009280656],"category_scores_gemma":[0.000100687,0.00009609527,0.0001100373,0.0001022575,0.0001851502,0.000206609,0.0002028832,0.0002285459,0.0002582254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344767,"about_ca_system_score_gemma":0.00009965018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002430184,"about_ca_topic_score_gemma":0.0003412311,"domain_scores_codex":[0.9998978,0.00001720856,0.000009399221,0.00002273359,0.00002826146,0.00002454225],"domain_scores_gemma":[0.9998215,0.00001800036,0.00005728796,0.00001976246,0.00002193369,0.00006150058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000090281,0.000006751247,0.0003610045,0.00001456079,0.000001978715,0.00003772927,0.000007197468,0.00002006414,0.9986709,0.00006500389,0.00001125936,0.0007132507],"study_design_scores_gemma":[0.00001186472,0.0002464883,0.01727062,0.000006451374,0.00001347122,0.000409968,0.00006758891,0.0007180848,0.9794342,0.0001217177,0.001696322,0.000003239935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960675,0.00157334,0.001259692,0.00005439562,0.00001175549,0.000005024661,0.000140426,0.00006306609,0.000824715],"genre_scores_gemma":[0.9984926,0.0003739885,0.000270237,0.000009095987,0.000003438626,0.000002527199,0.0001092647,0.000006842099,0.000731974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009280656,"threshold_uncertainty_score":0.003104746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008619237766587177,"score_gpt":0.2626000322079184,"score_spread":0.2539807944413312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}