{"id":"W2545908345","doi":"10.1038/ncomms13171","title":"Mitochondrial function controls intestinal epithelial stemness and proliferation","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Deutsche Forschungsgemeinschaft","keywords":"Biology; Stem cell; Cell biology; Wnt signaling pathway; Paracrine signalling; Intestinal epithelium; HSP60; Epithelium; Cancer research; Heat shock protein; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005722604,0.00008616228,0.00007215927,0.00002344769,0.0001419318,0.00002663711,0.0002070004,0.0001608364,0.000008052923],"category_scores_gemma":[0.0003162528,0.0000594291,0.00003677927,0.00003637639,0.0001196402,0.000007575789,0.0001330619,0.0001204338,0.000005792734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007996013,"about_ca_system_score_gemma":0.00004562471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002784705,"about_ca_topic_score_gemma":0.00007462353,"domain_scores_codex":[0.9994466,0.00008874882,0.0001246829,0.0001702344,0.00007256464,0.00009714476],"domain_scores_gemma":[0.9990627,0.00005679413,0.00005865678,0.0006287086,0.0001273219,0.00006585964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003453061,0.0001012523,0.01349329,0.000008099538,0.0000411763,4.559641e-7,0.00001521392,0.000002056095,0.9645205,0.01063201,0.002862625,0.007978029],"study_design_scores_gemma":[0.01383964,0.001464664,0.1160022,0.0002985804,0.0004036434,0.0001325099,0.0001800376,0.000739028,0.2457938,0.004974859,0.6148573,0.001313713],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575574,0.008762125,0.02200532,0.006849595,0.0007311371,0.000817558,0.0001996338,0.0000666015,0.003010631],"genre_scores_gemma":[0.9976581,0.0004176686,0.0009893936,0.0002448571,0.0002445074,0.00008434985,0.0001141649,0.000009296599,0.0002376151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7187267,"threshold_uncertainty_score":0.2423448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008619237766587177,"score_gpt":0.2626000322079184,"score_spread":0.2539807944413312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}