{"id":"W2546157736","doi":"10.1371/journal.ppat.1005982","title":"Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; McGill University; Leids Universitair Medisch Centrum; University of Wisconsin-Madison","keywords":"Protein kinase R; Stress granule; Biology; Interferon; Picornavirus; RNA silencing; EIF-2 kinase; Antiviral protein; Virology; Signal transduction; Integrated stress response; Coronavirus; Viral replication; Innate immune system; Virus; Phosphorylation; Protein kinase A; Cell biology; Translation (biology); RNA; Immune system; RNA interference; Immunology; Messenger RNA; Gene; Mitogen-activated protein kinase kinase; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829874,0.0003693623,0.0003901156,0.0002121073,0.0001633513,0.000336691,0.0002461622,0.000281811,0.00124158],"category_scores_gemma":[0.000215508,0.0001357424,0.00034004,0.0001317695,0.000225617,0.0002445189,0.0002189463,0.0006917554,0.0004492298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200071,"about_ca_system_score_gemma":0.0003472245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003932992,"about_ca_topic_score_gemma":0.0004477715,"domain_scores_codex":[0.9998092,0.00004382604,0.00002697123,0.00002649538,0.00004158755,0.00005193227],"domain_scores_gemma":[0.9998518,0.00003852089,0.00003117726,0.00002392352,0.00001817158,0.00003639003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002628794,0.0001091177,0.0001378837,0.00004182706,0.000008541102,0.00002336673,0.000008518919,0.00005912016,0.9980322,0.0000628249,0.00006995937,0.001183655],"study_design_scores_gemma":[0.00006294683,0.0009929315,0.003781318,0.000009341668,0.00001933121,0.0001758975,0.00002369935,0.001817128,0.9901257,0.00005964013,0.002926171,0.000005941109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942803,0.001919728,0.001452883,0.0001984138,0.00008069545,0.00004219815,0.0002759649,0.0001037679,0.001646028],"genre_scores_gemma":[0.9947622,0.0009888367,0.001646841,0.00007908208,0.00002247308,0.00004889761,0.0005789484,0.00002228722,0.001850239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124158,"threshold_uncertainty_score":0.00415355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05976134773801228,"score_gpt":0.2709689533789819,"score_spread":0.2112076056409696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}