{"id":"W2546157736","doi":"10.1371/journal.ppat.1005982","title":"Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; McGill University; Leids Universitair Medisch Centrum; University of Wisconsin-Madison","keywords":"Protein kinase R; Stress granule; Biology; Interferon; Picornavirus; RNA silencing; EIF-2 kinase; Antiviral protein; Virology; Signal transduction; Integrated stress response; Coronavirus; Viral replication; Innate immune system; Virus; Phosphorylation; Protein kinase A; Cell biology; Translation (biology); RNA; Immune system; RNA interference; Immunology; Messenger RNA; Gene; Mitogen-activated protein kinase kinase; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348917,0.000217547,0.000163307,0.00007737529,0.0001077699,0.00003151118,0.0002096271,0.0001853143,0.0001009613],"category_scores_gemma":[0.0004532266,0.0001666238,0.000109459,0.0001073459,0.0001515392,0.00001513521,0.0001386557,0.00005773249,0.0001734494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331695,"about_ca_system_score_gemma":0.0001780072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000215228,"about_ca_topic_score_gemma":0.00001838953,"domain_scores_codex":[0.9984515,0.0002274213,0.00026703,0.0004684921,0.0002510468,0.0003344946],"domain_scores_gemma":[0.9990252,0.00002348601,0.0001295729,0.0004795337,0.0001402452,0.0002019282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005465824,0.0002027917,0.03792447,0.00002399814,0.00003345301,0.00002822074,0.0000284578,7.609083e-7,0.958967,0.00003268303,0.0002442396,0.001967379],"study_design_scores_gemma":[0.001375333,0.0002168668,0.05511231,0.000115544,0.0000242084,0.000002215752,0.00005630085,0.000009466989,0.9362174,0.00002540482,0.006497766,0.0003472359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970687,0.0004983635,0.00006898076,0.0001500916,0.00006843593,0.0003817622,0.0009876271,0.00005742763,0.0007185852],"genre_scores_gemma":[0.9969259,0.00002328114,0.00008161616,0.0003578388,0.0002320248,0.00008142027,0.0001196204,0.0000423122,0.002135971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02274961,"threshold_uncertainty_score":0.6794721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05976134773801228,"score_gpt":0.2709689533789819,"score_spread":0.2112076056409696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}