{"id":"W2546616443","doi":"10.1016/j.ceca.2016.10.004","title":"Ligand binding to Ryanodine Receptors revealed through cryo-electron microscopy","year":2016,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Cryo-electron microscopy; Biophysics; Electron microscope; Receptor; Ligand (biochemistry); Chemistry; Crystallography; Cell biology; Biology; Biochemistry; Physics; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988713,0.000306963,0.0001986591,0.0002304274,0.0006560839,0.0004940665,0.0005134076,0.0006200189,0.002627327],"category_scores_gemma":[0.0002338137,0.0003359648,0.0001547237,0.0001702648,0.0005043237,0.0007363426,0.0003252265,0.00131872,0.000656881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668734,"about_ca_system_score_gemma":0.0002546459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002336636,"about_ca_topic_score_gemma":0.002795715,"domain_scores_codex":[0.999943,0.00000692365,0.000003805889,0.00001344202,0.00001653132,0.00001620406],"domain_scores_gemma":[0.9998506,0.00005850816,0.00001999037,0.00002500897,0.00003390872,0.0000119928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001187249,0.00002724256,0.0004253607,0.0001032068,0.00001266375,0.0003460116,0.0000870129,0.0004836129,0.9947768,0.001466639,0.0002557444,0.001897004],"study_design_scores_gemma":[0.00006943965,0.000197071,0.01702891,0.00008044585,0.00004644726,0.001953262,0.0003323302,0.0108861,0.9528834,0.001390663,0.01510751,0.00002442622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935329,0.004162622,0.03920428,0.0009346792,0.0001238079,0.00009554406,0.0008084243,0.0003191824,0.01902253],"genre_scores_gemma":[0.9673605,0.002603315,0.01978407,0.000259925,0.0000334904,0.00009886096,0.0005029804,0.0001615969,0.0091952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002627327,"threshold_uncertainty_score":0.008789241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1180187159909971,"score_gpt":0.4409372870713758,"score_spread":0.3229185710803787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}