{"id":"W2546713708","doi":"10.1182/blood.v126.23.1732.1732","title":"Impact of High Risk Prognostic Parameters and Addition of Ibrutinib to Bendamustine/Rituximab (BR) on Outcomes for Patients with Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) from the Phase 3 Double-Blind HELIOS Trial","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Ibrutinib; Medicine; Internal medicine; Chemoimmunotherapy; Bendamustine; Chronic lymphocytic leukemia; Population; Oncology; Clinical endpoint; Rituximab; Placebo; Randomized controlled trial; Lymphoma; Leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003743771,0.001288071,0.00267691,0.0003418258,0.0004074401,0.001386533,0.000785194,0.001279399,0.003586617],"category_scores_gemma":[0.002134677,0.0004345441,0.003870885,0.0003229312,0.0007683288,0.001027902,0.000633426,0.002972274,0.0004973097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006066244,"about_ca_system_score_gemma":0.0008281159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000405848,"about_ca_topic_score_gemma":0.0009204947,"domain_scores_codex":[0.9986292,0.000737455,0.0001303608,0.0002555639,0.000118771,0.0001286326],"domain_scores_gemma":[0.9984012,0.0004978906,0.000416582,0.0001246235,0.0001007316,0.0004590009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9763517,0.001800572,0.003834168,0.0005362097,0.002890689,0.00002219015,0.00003442956,0.0003702084,0.001838959,0.00006126282,0.0005831251,0.01167656],"study_design_scores_gemma":[0.8037658,0.1619998,0.02285206,0.0001798866,0.007250958,0.00008070347,0.0000516955,0.0006912884,0.001142271,0.0004327924,0.001507537,0.00004517135],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820079,0.01267639,0.0003570651,0.0006351487,0.0003982652,0.000989983,0.00125016,0.00003830181,0.001646861],"genre_scores_gemma":[0.9933382,0.001862783,0.0004172053,0.0007167759,0.0003922407,0.0009275309,0.00156919,0.00001018157,0.0007659333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003743771,"threshold_uncertainty_score":0.01979917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808015408571269,"score_gpt":0.3236016381806813,"score_spread":0.2755214840949686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}