{"id":"W2546886006","doi":"10.1158/2326-6066.imm2016-a144","title":"Abstract A144: Urease-mediated alkalization of tumor microenvironment and its effects on T cell proliferation, cytokine release, and PD-1/PD-L1 interactions","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"","keywords":"Tumor microenvironment; Jurkat cells; Cancer cell; Cytotoxic T cell; Cytokine; Chemistry; Immunoconjugate; Cancer immunotherapy; Cancer research; Immunotherapy; Cell culture; T cell; Immune system; Biology; Molecular biology; Biochemistry; Cancer; In vitro; Immunology; Antibody; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008494565,0.0002247907,0.0001588275,0.00009318866,0.00007370961,0.0001472286,0.000105636,0.0001870094,0.001928852],"category_scores_gemma":[0.0000646587,0.00005950123,0.0001766725,0.00008106227,0.0001111097,0.0001063576,0.0001022229,0.0002488242,0.0002711575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281506,"about_ca_system_score_gemma":0.0001022121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002426628,"about_ca_topic_score_gemma":0.0002045042,"domain_scores_codex":[0.9999346,0.0000111573,0.000005666089,0.00001272625,0.00001813093,0.00001771843],"domain_scores_gemma":[0.9999647,0.000006349124,0.00001127656,0.000003007956,0.000005808331,0.000008731477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001702294,0.0000250829,0.000128191,0.00002926593,0.000002363961,0.0000323621,0.000005349373,0.00003891215,0.9985453,0.0000229409,0.00003642162,0.0009636119],"study_design_scores_gemma":[0.0000170458,0.000570997,0.00135599,0.000002374237,0.000004972801,0.00008879551,0.000007122964,0.0002951045,0.9967739,0.00001217616,0.0008698058,0.000001666382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964433,0.001244634,0.001032767,0.00004741795,0.0000287558,0.00002684523,0.000200168,0.00003039412,0.0009456681],"genre_scores_gemma":[0.9964204,0.0005085374,0.0008838184,0.0000445404,0.00001255594,0.00002856327,0.0003345966,0.000005883795,0.001761086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928852,"threshold_uncertainty_score":0.00645268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716459841381276,"score_gpt":0.3176981410609099,"score_spread":0.3005335426470972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}