{"id":"W2546886006","doi":"10.1158/2326-6066.imm2016-a144","title":"Abstract A144: Urease-mediated alkalization of tumor microenvironment and its effects on T cell proliferation, cytokine release, and PD-1/PD-L1 interactions","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"","keywords":"Tumor microenvironment; Jurkat cells; Cancer cell; Cytotoxic T cell; Cytokine; Chemistry; Immunoconjugate; Cancer immunotherapy; Cancer research; Immunotherapy; Cell culture; T cell; Immune system; Biology; Molecular biology; Biochemistry; Cancer; In vitro; Immunology; Antibody; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871303,0.0001322976,0.0001479175,0.0001471365,0.0001334496,0.00001597043,0.0001052733,0.00009081519,0.00009189254],"category_scores_gemma":[0.0002022122,0.00009955531,0.00002814174,0.0001085838,0.0002369786,0.00001331881,0.0001289825,0.0001576244,0.00002273686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001946,"about_ca_system_score_gemma":0.0001505235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001499981,"about_ca_topic_score_gemma":0.0001525604,"domain_scores_codex":[0.9987495,0.0001624592,0.0001725865,0.0003871178,0.0001910723,0.0003372684],"domain_scores_gemma":[0.9992887,0.0001257017,0.00006823315,0.0002434858,0.0001663348,0.0001074848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169245,0.0001559231,0.008830273,0.00008017804,0.0001299767,0.00001207287,0.00003126297,0.000001756763,0.9832534,0.00001955838,0.001000081,0.005316334],"study_design_scores_gemma":[0.00203828,0.0008858671,0.06401688,0.0001043985,0.00001148629,0.00001273343,0.00001779409,0.00000843555,0.9244004,0.00003122434,0.008376406,0.00009612581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900028,0.008377905,0.00001770995,0.0007104329,0.00005750592,0.0005335798,0.0001457494,0.000006085364,0.00014829],"genre_scores_gemma":[0.988489,0.01008712,0.00001047841,0.00005760893,0.00008040733,0.0003104234,0.0001030617,0.00002037064,0.000841548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05885297,"threshold_uncertainty_score":0.4059747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716459841381276,"score_gpt":0.3176981410609099,"score_spread":0.3005335426470972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}