{"id":"W2547010172","doi":"10.1194/jlr.p071639","title":"Defective cholesterol metabolism in amyotrophic lateral sclerosis","year":2016,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Biotechnology and Biological Sciences Research Council; Svenska Forskningsrådet Formas; Motor Neurone Disease Association","keywords":"Amyotrophic lateral sclerosis; Cholesterol; Neurodegeneration; Sterol; Metabolite; Cerebrospinal fluid; Central nervous system; Neuroprotection; Internal medicine; Endocrinology; Oxysterol; Chemistry; Biology; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554954,0.0005329476,0.0003266338,0.0009874593,0.0003141368,0.0002447001,0.0001230396,0.0003943893,0.0008993989],"category_scores_gemma":[0.0002177698,0.0001654525,0.0001683446,0.0003879023,0.0004992218,0.0001347063,0.0003178398,0.0002381615,0.0003031456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877201,"about_ca_system_score_gemma":0.0002082299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357156,"about_ca_topic_score_gemma":0.001075368,"domain_scores_codex":[0.9999207,0.00001390711,0.00001286887,0.00001767226,0.00002630507,0.000008529408],"domain_scores_gemma":[0.9998986,0.00001176663,0.00004532152,0.00000728807,0.00001403048,0.00002304093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003607288,0.0002115944,0.1764947,0.0002418944,0.000161447,0.01712836,0.0009778506,0.0003462909,0.7789158,0.0003231226,0.0005494243,0.0210422],"study_design_scores_gemma":[0.00008589534,0.001230831,0.8975962,0.00005565228,0.000141187,0.03343883,0.0007319932,0.0007846811,0.06072048,0.001487825,0.003697337,0.00002896082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977486,0.001280273,0.0001664544,0.00006386563,0.000008196018,0.000006279252,0.0001223522,0.00002592355,0.000578052],"genre_scores_gemma":[0.9982694,0.000733204,0.000161822,0.00005154046,0.000008663536,0.000007891626,0.0001378581,0.000003487862,0.0006260372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357156,"threshold_uncertainty_score":0.003008783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04986503632611848,"score_gpt":0.3296751566995871,"score_spread":0.2798101203734686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}