{"id":"W2547010172","doi":"10.1194/jlr.p071639","title":"Defective cholesterol metabolism in amyotrophic lateral sclerosis","year":2016,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Biotechnology and Biological Sciences Research Council; Svenska Forskningsrådet Formas; Motor Neurone Disease Association","keywords":"Amyotrophic lateral sclerosis; Cholesterol; Neurodegeneration; Sterol; Metabolite; Cerebrospinal fluid; Central nervous system; Neuroprotection; Internal medicine; Endocrinology; Oxysterol; Chemistry; Biology; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001596962,0.0001314504,0.0002509676,0.0004200147,0.00006524489,0.00004148757,0.000379552,0.000171585,0.00006623098],"category_scores_gemma":[0.0005031779,0.00008171841,0.0001354735,0.0003037776,0.0001705299,0.00002542763,0.0001645365,0.0004885416,0.00002830627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009278446,"about_ca_system_score_gemma":0.0002059807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009661595,"about_ca_topic_score_gemma":0.000009064788,"domain_scores_codex":[0.9978173,0.0005787237,0.0003825778,0.000234222,0.0005281752,0.000458998],"domain_scores_gemma":[0.9988663,0.00005966308,0.0001368828,0.0002306751,0.0005222724,0.0001841691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003770537,0.0001044145,0.0238935,0.000005429601,0.00006457434,0.000006749865,0.00005524602,0.000005629671,0.9694707,0.000007485083,0.002172557,0.003836639],"study_design_scores_gemma":[0.001864359,0.0005184116,0.06229436,0.000129902,0.000004682301,0.00005304406,0.00003356345,0.000001731061,0.9112942,0.00007517076,0.02360849,0.0001221487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970215,0.0005593125,0.00007160231,0.001731711,0.0003130551,0.0001202739,0.000006047071,0.000002954212,0.0001735228],"genre_scores_gemma":[0.9971335,0.001427126,0.0001289431,0.0001307292,0.00090348,0.00001134686,9.711889e-7,0.00002706262,0.0002368192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05817658,"threshold_uncertainty_score":0.333238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04986503632611848,"score_gpt":0.3296751566995871,"score_spread":0.2798101203734686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}