{"id":"W2547041422","doi":"10.1158/2326-6066.imm2016-b028","title":"Abstract B028: Blockade of the CD47 “Do not eat” signal by TTI-621 (SIRPαFc) leads to enhanced antitumor CD8+ T cell responses in vitro","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Jurkat cells; Phagocytosis; CD47; Macrophage; T cell; Antigen; Biology; Antigen presentation; CD8; Cell biology; Molecular biology; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00139248,0.0002790639,0.0005648177,0.0004608023,0.0003223816,0.00002150423,0.001099632,0.0004889836,0.001266091],"category_scores_gemma":[0.0003596049,0.0001821571,0.0001612783,0.0006772827,0.001330582,0.0001641284,0.0004753459,0.0008744696,0.0003676945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357735,"about_ca_system_score_gemma":0.0005447162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410719,"about_ca_topic_score_gemma":0.00005152986,"domain_scores_codex":[0.9962817,0.001138859,0.000666717,0.0006303144,0.0001871255,0.001095277],"domain_scores_gemma":[0.9975677,0.0009555988,0.0002093746,0.0008841993,0.0003435417,0.00003955272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004351053,0.0002179349,0.002172234,0.00002501445,0.00009798807,0.000002867487,0.0003625648,0.00000387825,0.9728248,0.00004857194,0.003020302,0.01687277],"study_design_scores_gemma":[0.002105673,0.0002731638,0.07706897,0.0001835892,0.00001122958,0.000008057168,0.0001412582,3.847719e-7,0.9078302,0.00004474722,0.01212853,0.0002041516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813583,0.01347075,0.00002528415,0.00299911,0.0005717499,0.0006477395,0.0002001841,0.00002818289,0.0006986576],"genre_scores_gemma":[0.9880099,0.001060651,0.0000128456,0.00009080025,0.00004274257,0.0002301616,0.00001675457,0.00003679869,0.01049937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07489673,"threshold_uncertainty_score":0.9996469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04044189781863931,"score_gpt":0.3396606586410613,"score_spread":0.299218760822422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}