{"id":"W2547041422","doi":"10.1158/2326-6066.imm2016-b028","title":"Abstract B028: Blockade of the CD47 “Do not eat” signal by TTI-621 (SIRPαFc) leads to enhanced antitumor CD8+ T cell responses in vitro","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Jurkat cells; Phagocytosis; CD47; Macrophage; T cell; Antigen; Biology; Antigen presentation; CD8; Cell biology; Molecular biology; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811991,0.0005432547,0.0004260395,0.000170497,0.0001429385,0.0002949692,0.0002225818,0.0004277097,0.00213939],"category_scores_gemma":[0.0001191659,0.0001531982,0.0002659568,0.0001400038,0.0001820488,0.0001452416,0.0001396668,0.00115268,0.001025509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001625006,"about_ca_system_score_gemma":0.0002062521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005472059,"about_ca_topic_score_gemma":0.0003980578,"domain_scores_codex":[0.9997789,0.00004600585,0.00002392591,0.00002982245,0.0000452834,0.00007604915],"domain_scores_gemma":[0.9998316,0.00003636036,0.00002422998,0.00002085807,0.00001418277,0.0000728068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008491856,0.0003099125,0.00006162497,0.00003337891,0.000006732114,0.00005331824,0.00001466343,0.00008815811,0.9973328,0.00004536402,0.0001293536,0.00107537],"study_design_scores_gemma":[0.0001891218,0.00441321,0.002236511,0.000009341868,0.00002176306,0.0002317472,0.00002315725,0.001067418,0.9899797,0.00003060614,0.001792091,0.000005314108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951439,0.0008985972,0.0009200946,0.0001360195,0.0001013173,0.00005632829,0.0004694716,0.00008944731,0.002184879],"genre_scores_gemma":[0.9935271,0.0004368663,0.0009318251,0.0001126592,0.00003791789,0.00007704731,0.001090118,0.00002798771,0.003758445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213939,"threshold_uncertainty_score":0.007156968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04044189781863931,"score_gpt":0.3396606586410613,"score_spread":0.299218760822422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}