{"id":"W2547251167","doi":"10.1182/blood.v122.21.1474.1474","title":"Effectively Targeting Treatment-Naïve CML Stem/Progenitor Cells From Imatinib-Nonresponders With Combination Treatments Of JAK2 and ABL Inhibitors In Vitro and In Vivo","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Stem cell; Imatinib mesylate; Progenitor cell; Dasatinib; Nilotinib; Cancer research; Imatinib; Tyrosine kinase; CD34; Haematopoiesis; K562 cells; Tyrosine-kinase inhibitor; Myeloid leukemia; Medicine; Biology; Immunology; Leukemia; Internal medicine; Cell biology; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860763,0.0002869827,0.0004695654,0.0001985436,0.0001012624,0.0002139926,0.0001748573,0.000157604,0.001665027],"category_scores_gemma":[0.00008901139,0.0001148013,0.0001838875,0.0001248654,0.00008881374,0.0001448575,0.0001047154,0.0005962603,0.0003349504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009924372,"about_ca_system_score_gemma":0.0001401305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001980374,"about_ca_topic_score_gemma":0.0004013394,"domain_scores_codex":[0.9998823,0.00002249875,0.00001293515,0.00002336784,0.00003322932,0.00002552204],"domain_scores_gemma":[0.9999475,0.00001064135,0.000009133527,0.00001070777,0.000006309521,0.00001554664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008057769,0.0006062542,0.000476123,0.00006755392,0.00002366725,0.00003716591,0.00002980592,0.0002253125,0.9907225,0.00007998606,0.000213225,0.006712596],"study_design_scores_gemma":[0.000447036,0.01422172,0.01566008,0.000009690764,0.0001139502,0.0005153969,0.00006729888,0.002715671,0.961754,0.00006218973,0.004424608,0.000008296574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975467,0.0007306435,0.0005977253,0.00004315459,0.00003074205,0.00006262551,0.0002310087,0.00003204678,0.0007252691],"genre_scores_gemma":[0.99612,0.0004738272,0.0009867239,0.00005673945,0.00001968676,0.00009559996,0.000873205,0.00001009303,0.001364184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001665027,"threshold_uncertainty_score":0.005570054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00753092431805815,"score_gpt":0.2214598851412538,"score_spread":0.2139289608231956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}